Cardiovascular Disease
Conditions
Brief summary
Pilot study data have demonstrated that peanuts ameliorate the postprandial glucose and insulin response when incorporated into an acute high fat/high glucose meal. However, it is unclear whether acute consumption of peanuts can also influence vascular function. This study will therefore evaluate the effects of acute peanut consumption on vascular function, glycemic control, and plasma lipids. The hypothesis is that that addition of peanuts to a high fat/high glucose meal will reduce the production of triglycerides, glucose, and improve endothelial function as measured by flow-mediated dilation (FMD).
Interventions
DIETARY_SUPPLEMENTControl
34.8 g dextrose, 150 g heavy whipping cream, 39g chocolate syrup, 15 g sunflower oil, 22 g safflower oil, 27 g powdered egg whites, 9.6 g of fiber supplement, water and crushed ice. It will deliver \ 1200 kcal.
DIETARY_SUPPLEMENTPeanut
34.8 g dextrose. 137 g heavy whipping cream, 39g chocolate syrup + 3 oz peanuts with skin. It will deliver \ 1200 kcal.
Sponsors
Peanut Institute
Penn State University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
MALE
Age
20 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* 20-50 years of age * LDL-C below 160 mg/dL * Triglyceride below 350 mg/dL * Blood pressure within normal ranges (below 140/90 mmHg) * Not taking medication for elevated lipids, blood pressure or glucose
Exclusion criteria
* Allergies to peanuts or dairy products * Known intolerance for high fat meals * History of cardiovascular disease (CVD), kidney disease, diabetes or inflammatory diseases such as GI disorders and arthritis * Use of non-steroidal anti-inflammatories or immunosuppressants * Conditions requiring the use of steroids * Use of medication or supplements for elevated lipids, blood pressure or glucose * Donation of blood or plasma during the study * History of thyroid disease * Women * Lactose intolerance
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change from baseline in Flow-Mediated Dilation at 4 hours postprandial | 0 min; 240 min |
Secondary
| Measure | Time frame |
|---|---|
| Change from baseline in oxidative stress over 4 hours postprandial | 0 min, 30 min, 60 min, 120 min, 240 min |
| Change from baseline in serum lipids over 4 hours postprandial | 0 min, 30 min, 60 min, 120 min, 240 min |
| Change from baseline in serum glucose over 4 hours postprandial | 0 min, 30 min, 60 min, 120 min, 240 min |
| Change from baseline in serum insulin over 4 hours postprandial | 0 min, 30 min, 60 min, 120 min, 240 min |
Countries
United States
Outcome results
None listed