Cellular and Humoral Immunity in Elderly After Immunization With a Japanese Encephalitis Vaccine

Characterisation of Cellular and Humoral Immunity in Elderly People After Immunization With a Purified, Inactivated Japanese Encephalitis Vaccine.

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01398540

Enrollment

Registered

2011-07-20

Start date

2010-11-30

Completion date

2013-11-30

Last updated

2018-03-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Humoral and Cellular Immune Responses

Brief summary

The aim of this project is to investigate humoral and cellular immune responses before and after immunisation with the Japanese encephalitis vaccine IXIARO in subjects above 60 years of age and 18-40 years old subjects.

Interventions

BIOLOGICALIXIARO

2 immunizations (0,5ml) with a 28 day interval

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 99 Years

Healthy volunteers

Yes

Inclusion criteria

* adults (18-40 years old) * adults (≥60 years), * both sexes * willingness to sign written informed consent form

Exclusion criteria

* age below 18 years or between 41-59 years old * status post japanese encephalitis, tick born encephalitis (TBE), dengue, yellow fever or West Nile virus infection * previous immunization against yellow fever, japanese encephalitis (dengue or WNV) * current acute infection (body temperature above 37,9°C)

Design outcomes

Primary

Measure	Time frame
cellular immunity (cytokine production upon stimulation with Japanese Encephalitis (JE) Virus Antigen) 7 days after the 2. JE-vaccination	7 days after the 2 JE vaccinations

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026