Effects of Betaine Supplementation on Strength and Muscle Creatine Content

Effects of Betaine Supplementation Combined or Not With Creatine Supplementation on Muscle Creatine Content and Strength

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01213719

Enrollment

Registered

2010-10-04

Start date

2010-10-31

Completion date

2011-07-31

Last updated

2012-01-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Subjects

Keywords

betaine, creatine, strength

Brief summary

It has been suggested that betaine supplementation may improve muscle strength by increasing muscle creatine content. However, there is no data supporting this assumption. The investigators speculate that betaine supplementation could enhance intramuscular creatine content, which would result in strength improvements.

Interventions

DIETARY_SUPPLEMENTcreatine

20g/d throughout 10 days

DIETARY_SUPPLEMENTbetaine

2g/d throughout 10 days

DIETARY_SUPPLEMENTdextrose

dextrose (placebo), 20 g/d throughout 10 days

DIETARY_SUPPLEMENTcreatine plus betaine

creatine (20g/d) plus betaine (2g/d) throughout 10 days

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

MALE

Age

18 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

* physically inactive * non-obese

Exclusion criteria

* skeletal muscle disturbance * cardiovascular disturbance * use of dietary supplements

Design outcomes

Primary

Measure	Time frame
strength	after 10 days

Secondary

Measure	Time frame
intramuscular creatine content	after 10 days

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026