Effect of Enzyme Therapy on Protein Metabolism in Chronic Pancreatitis

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01154608

Enrollment

Registered

2010-07-01

Start date

2005-04-30

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pancreatitis

Keywords

Protein absorption in pancreatitis, Protein metabolism in pancreatitis

Brief summary

Pancreatic exocrine insufficiency is known to impair nutrient absorption, especially fat, but few data exist about protein absorption. We aimed to investigate this question and assess the enzyme substitution efficiency using a sensitive method.

Interventions

DRUGCreon

OTHERNo enzyme therapy

Current enzyme therapy of the patient is stopped during 7 days

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Chronic pancreatitis * Pancreatic insufficiency * Enzyme therapy treatment

Exclusion criteria

* Hepatic failure * Pregnancy * Positive serology to HIV, HCV, AGHbS, gastro-intestinal disease

Design outcomes

Primary

Measure	Time frame
transfer of dietary nitrogen to metabolic pools	—

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026