Appetite Suppression, Weight Loss
Conditions
Keywords
viscous, fibre, polysaccharide, appetite, hunger, satiety, weight management
Brief summary
This 18 week, randomized, double blind, placebo controlled trial will examine the effects of thick dietary fibre (PGX) supplementation of a low calorie diet (LCD) on appetite, weight loss, body composition, and compliance in overweight and moderately obese female. The investigators believe that 15 grams/day PGX supplementation of a low calorie diet over a 14-weeks period will elicit a better appetite score (e.g. reduced hunger) compared to the rice flour supplementation of the LCD.
Interventions
DIETARY_SUPPLEMENTPolyGlycopleX (PGX)
The full dose of the study intervention is 15 grams per day and total number of calories with the LCD is 1000 kcal/day.
DIETARY_SUPPLEMENTRice flour
The full dose of the placebo comparator is 15 grams per day and total number of calories with the LCD is 1000 kcal/day.
Sponsors
University of British Columbia
InovoBiologic Inc.
Canadian Center for Functional Medicine
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI 25 - 35 Kg/m2
Exclusion criteria
* Medications and supplements that affect appetite * Known diabetes * Contraindications to LCD * Any other medical, social or geographic condition, which, in the opinion of the investigator would not allow safe completion of the protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The difference in appetite score assessed from appetite Visual Analog Scale | 18 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Change in weight (kilograms) | 18 weeks |
| Change in percentage of body fat | 18 weeks |
Countries
Canada
Outcome results
None listed