Evaluation of Subjective Ratings of Appetite and Glucoregulation of a Low Calorie Diet Supplemented With a High Viscosity Polysaccharide (PolyGlycopleX - PGX)

A Prospective, Single Crossover, Randomized, Double Blind Placebo Controlled Trial Evaluating Subjective Ratings of Appetite and Glucoregulation of a Low Calorie Diet Supplemented With a High Viscosity Polysaccharide (PolyGlycopleX - PGX) vs. Rice Flour Control, in Overweight and Moderately Obese Females.

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01108328

Enrollment

Registered

2010-04-22

Start date

2010-06-30

Completion date

2010-11-30

Last updated

2015-10-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Appetite and Hunger, Suppression, Blood Glucose, Postprandial

Keywords

viscous, fibre, polysaccharide, blood glucose, postprandial, appetite, hunger, satiety

Brief summary

The objective of the study is to compare subjective appetite ratings and after-meal and 24 hour blood glucose levels within overweight and obese female subjects consuming either a standardized 3 day low calorie diet supplemented with a viscous fibre known as PGX (treatment) or a rice flour (placebo control). Each treatment phase will be 3 days in length and separated by 3 week washout phase, so subjects will also be acting as their own control. Subjects will be randomized to either start with the low calorie diet with PGX or the low calorie diet supplemented with rice flour. We hypothesize that the 3 day LCD with PGX will elicit an improved appetite score compared to the 3 day LCD supplemented with the rice flour placebo control.

Interventions

DIETARY_SUPPLEMENTPolyGlycopleX (PGX)

powder, 5 grams, 3 times per day at each main meal (breakfast, lunch and dinner) for a total of 3 days

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

\- BMI 25-35 Kg/m2

Exclusion criteria

* Known diabetes * Medications or natural health products that affect appetite * Contraindications to LCD * Any other medical, social or geographic condition, which, in the opinion of the investigator would not allow safe completion of the protocol.

Design outcomes

Primary

Measure	Time frame
Change in the ratings of the variables in the Appetite Visual Analog Scale and the overall Appetite Score.	3 days

Secondary

Measure	Time frame
Changes in 2-hour postprandial areas under the curve (AUC) and 24 hour blood glucose (CGMS) profiles.	3 days

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026