Hepatic Encephalopathy, Hypertension, Portal, Liver Cirrhosis
Conditions
Keywords
Hepatic Encephalopathy, Hypertension, Portal, Liver Cirrhosis, Bacterial Overgrowth Syndrome
Brief summary
Comparison between the efficacy of two different antibiotics in patients with overt hepatic encephalopathy. The study is randomized, controlled and double-blinded.
Interventions
DRUGErythromycin
250 mg orally q.i.d.
DRUGNeomycin
1 g orally q.i.d.
Sponsors
Biophisics Department of Biosciences Institute - Unesp
Conselho Nacional de Desenvolvimento Científico e Tecnológico
UPECLIN HC FM Botucatu Unesp
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Hepatic cirrhosis or portal hypertension * Hepatic Encephalopathy
Exclusion criteria
* Acute liver failure * Neuropsychiatric diseases * Inflammatory bowel diseases * Intestinal obstruction * Shock * Renal insufficiency * Alcoholic hepatitis * Alcohol abuse * Antibiotic premedication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Recovery of hepatic encephalopathy | three years | comparison of efficacy between two drugs for the treatment of hepatic encephalopathy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| length of hospitalization caused by hepatic encephalopathy | three years | comparison of efficacy between two drugs for reducing the length of hospitalization during treatment of hepatic encephalopathy |
Countries
Brazil
Outcome results
None listed