Impact of Spices and Herbs on Endothelial Function

Investigation of the Impact of Spices and Herbs on Endothelial Function and Other CVD Risk Factors in Men and Women.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01085019

Enrollment

224

Registered

2010-03-11

Start date

2010-03-31

Completion date

2011-12-31

Last updated

2012-06-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endothelial Function

Keywords

Endothelial function, Cardiovascular risk factors, Spices, Herbs, Antioxidant

Brief summary

The general objective of the study is to investigate the effects of the daily consumption of spices and herbs for four (4) consecutive weeks in endothelial function and cardiovascular risk factors of men and postmenopausal women.

Detailed description

The purpose is to assess whether the polyphenol/antioxidant content of different spices will affect endothelial function and other cardiovascular risk factors.

Interventions

DIETARY_SUPPLEMENTCinnamon

2.8g/day of cinnamon in capsules during 4 weeks.

DIETARY_SUPPLEMENTOregano

2.8g/day of oregano in capsules during 4 weeks.

DIETARY_SUPPLEMENTGinger

2.8g/day of ginger in capsules during 4 weeks.

DIETARY_SUPPLEMENTRosemary

2.8g/day of rosemary in capsules during 4 weeks.

DIETARY_SUPPLEMENTBlack pepper

2.8g/day of black pepper in capsules for 4 weeks.

DIETARY_SUPPLEMENTPlacebo

2.8 g/day of placebo in capsules (corn starch) during 4 weeks.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender

ALL

Age

40 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* Age 40-70 yrs * Men and postmenopausal women * Waist girth \>102cm (men) or \>88cm (women) * LDL-C \> 2.8 mmol/L * Framingham 10-yr risk score \< 10% * Marginal endothelial dysfunction * Non smoker

Exclusion criteria

* Medication for lipid, hypertension, diabetes * History of CVD, diabetes, other endocrines disorders * Pre-menopausal women * Alcohol consumption \> 1 drink per day * Unusual dietary habits (e.g. vegetarism) * Chronic use of supplements (estrogens, vitamins, minerals or flavonoids) * Aversion or intolerance for spices and/or herbs * Injury to fingers or amrs that would interfere with endothelial function measurement

Design outcomes

Primary

Measure	Time frame
Endothelial function measured by endopat system (the endothelium-mediated changes in vacular tone)	at week 0 and week 4

Secondary

Measure	Time frame
Circulating level of plasma lipoproteins-lipids	at week 0 and week 4
Oxidative stress	at week 0 and week 4
Endothelial activation and inflammatory markers	at week 0 and week 4

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 10, 2026