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Reduction of the Glycemic Index by a Novel Viscous Polysaccharide

Effect of Adding the Novel Fiber, PGX®,to Commonly Consumed Foods on Glycemic Response and Glycemic Index: A Practical and Effective Strategy for Reducing Post Prandial Blood Glucose Levels.

Status
Completed
Phases
Phase 2Phase 3
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00935350
Enrollment
10
Registered
2009-07-09
Start date
2006-05-31
Completion date
2006-08-31
Last updated
2009-07-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Blood Glucose, Postprandial

Keywords

viscous, fibre, polysaccharide, blood glucose, postprandial

Brief summary

Reductions of postprandial glucose levels have been demonstrated previously with the addition of a novel viscous polysaccharide (NVP) to a glucose drink and standard white bread. This study explores whether these reductions are sustained when NVP is added to a range of commonly consumed foods.

Detailed description

Recently, a commercial novel viscous polysaccharide (NVP)complex has been developed which is marketed in both the USA and Canada under the trade name PGX® (PolyGlycopleX) (InovoBiologic Inc, Calgary, AB, Canada). This complex consists of three viscous non starch polysaccharides which are processed using proprietary technology (EnviroSimplex®) to produce compressed granules which delays the onset of viscosity and increases palatability of the fiber when added to food. Previously, this fibre was shown to lower postprandial glucose levels in a dose responsive manner when mixed with a glucose drink and sprinkled onto a standard white bread demonstrating that the processing did not interfere with the effectiveness of the fiber. From this study the reduction in GI was calculated to be 7 units per gram of NVP when added to a solid food, however it is not known whether this relationship would be maintained when the NVP was added to a range of commonly eaten foods. This study therefore evaluates the effect of the addition or incorporation of NVP into a range of foods on postprandial glycemia and whether the reductions in glycemic index could be predicted using.

Interventions

DIETARY_SUPPLEMENTPolyGlycopleX (PGX)

2.5 grams of PGX

Sponsors

InovoBiologic Inc.
CollaboratorINDUSTRY
Canadian Center for Functional Medicine
CollaboratorOTHER
Glycemic Index Laboratories, Inc
Lead SponsorINDUSTRY

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes

Inclusion criteria

* healthy individuals * 18-75 years old * BMI less than 35 kg/m2

Exclusion criteria

* Medications influencing gastrointestinal function * Pregnancy

Design outcomes

Primary

MeasureTime frame
Relative Blood glucose response of food with and without NVPAcute blood glucose response measured at 0, 15,30,45,60,90 and 120 min

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 30, 2026