Pharmacokinetics and Pharmacodynamics of Nasally Applied Esketamine

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00847418

Enrollment

Unknown

Registered

2009-02-19

Start date

2009-02-28

Completion date

2009-10-31

Last updated

2010-12-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain

Keywords

pharmacokinetics, ketamine, Anesthetics, Dissociative

Brief summary

The purpose of this study is the determination of blood concentration and the effectiveness of esketamine after nasal application.

Interventions

DRUGesketamine hydrochloride

Eligibility

Sex/Gender

MALE

Age

18 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* male * age ≥18 years ≤ 45 years * healthy * non-smoking * BMI 18-27

Exclusion criteria

* abuse of drugs * known or supposed hypersensitivity and/or contraindication against ketamine or additives * participation of another clinical study within the last 30 days * chronic obstructed nose breathing or nasal polyps * dug allergy * blood donation within the last two months

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026