Esketamine hydrochloride

DRUG12 trials

Conditions

Behavior ProblemBipolar DepressionChronic Pelvic Pain SyndromeDepressive SymptomsEndometriosisEsketamineHealthy VolunteersImmunosuppression

Early Phase 1

Esketamine for the Treatment of Rett Syndrome

CompletedNCT06199700

Children's Hospital of Fudan UniversityRett Syndrome

Start: 2023-11-15End: 2025-12-30Updated: 2026-05-13

Phase 1

Pharmacokinetics and Pharmacodynamics of Nasally Applied Esketamine

CompletedNCT00847418

University Hospital, Basel, SwitzerlandPain

Start: 2009-02-28End: 2009-10-31Updated: 2010-12-02

Phase 2

Ketamine Sedation As Neuroprotective Agent Following Out-of-hospital Cardiac Arrest

RecruitingNCT06744361

Christian HassagerOut-of-hospital Cardiac Arrest (OHCA)

Start: 2024-12-12End: 2027-09-01Target: 282Updated: 2024-12-20

Phase 3

Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment Failure

RecruitingNCT05603104

Dr. Inge WinterBipolar Depression, Major Depressive Disorder, Schizophrenia and Related Disorders

Start: 2025-04-27End: 2028-06-30Target: 1254Updated: 2026-01-22

The Effect of a Six Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.

RecruitingNCT05973851

Dr. Inge WinterMajor Depressive Disorder, Treatment Resistant Depression

Start: 2024-08-31End: 2028-06-30Target: 418Updated: 2025-09-26

Esketamine as Treatment for Chronic Pain Due to Endometriosis: a RCT Study

RecruitingNCT06161805

Reinier de Graaf GroepChronic Pelvic Pain Syndrome, Endometriosis

Start: 2024-03-01End: 2026-06-01Target: 56Updated: 2025-04-11

Phase 4

Immunoinflammatory Regulation of Esketamine in Septic Patients

RecruitingNCT04843982

Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyEsketamine, Immunosuppression, Inflammatory Response +1

Start: 2021-07-28End: 2026-10-30Target: 100Updated: 2025-07-18

Effects of Esketamine on Postoperative Behavioral Changes in Children Undergoing Tonsillectomy and/or Adenoidectomy

RecruitingNCT06579937

Fujian Provincial HospitalBehavior Problem

Start: 2024-09-02End: 2025-10-30Target: 172Updated: 2024-10-01

S-ketamine for cortical spreading depolarisation in patients with severe acute brain injury (KETA-BID trial)

RecruitingCTIS2024-515315-22-00

Rigshospitaletintracerebral hemorrhage, subarachnoid hemorrhage, traumatic brain injury

Start: 2023-09-15Target: 400Updated: 2025-03-25

Efficacy and Safety of S-ketamine in Elderly Patients Undergoing Non-cardiac Surgery: a RCT（ESSENCE）

Not yet recruitingNCT07063108

Chinese PLA General HospitalPostoperative Pain

Start: 2025-12-01End: 2026-12-31Target: 276Updated: 2025-07-14

Unknown Phase

Network Dysfunction, Schizophrenia and Pharmacological Magnetic Resonance Imaging (phMRI)

CompletedNCT01394757

Medical University of ViennaHealthy Volunteers

Start: 2011-08-31End: 2012-08-31Updated: 2013-12-31

Effect of Esketamine on Depressive Symptoms of Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy

NCT06199011

The Second Hospital of Anhui Medical UniversityDepressive Symptoms

Start: 2024-01-01End: 2025-12-01Target: 400Updated: 2024-01-10

Related Papers

INTENSIFY—a randomized, controlled trial to investigate the effect of an early intensified pharmacological treatment for major psychiatric disorders after treatment failure in the current episode: a study protocol

Trials2026-08-05

Cross-sectional analysis of ongoing clinical trials involving lamotrigine for mental disorders: Insights from ClinicalTrials.gov and the EU clinical trials.

2025-12-04

S-ketamine versus placebo for cortical spreading depolarisation in severe acute brain injury (KETA-BID): protocol for a pilot, randomised, blinded clinical trial

BMJ Open2025-07-011 citations

Esketamine infusion as treatment for chronic endometriosis-associated pain? Study protocol for a randomized controlled trial (EASYlight-study)

Journal of Endometriosis and Pelvic Pain Disorders2024-12-06