Lymphoma
Conditions
Keywords
stage III mantle cell lymphoma, stage IV mantle cell lymphoma
Brief summary
RATIONALE: Giving chemotherapy and monoclonal antibody therapy before a donor stem cell transplant helps stop the growth of cancer cells. It also helps stop the patient's immune system from rejecting the donor's stem cells. When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. PURPOSE: This phase II trial is studying donor stem cell transplant in treating patients with mantle cell lymphoma.
Detailed description
OBJECTIVES: Primary * Determine progression-free survival in patients with mantle cell lymphoma undergoing low-intensity allogeneic stem cell transplantation. Secondary * Determine overall survival of these patients. * Determine the toxicity by way of adverse event profile of this regimen in these patients. OUTLINE: This is a multicenter study. * Reduced intensity conditioning: Patients receive carmustine IV over 2 hours on day -6, etoposide IV over 1 hour and cytarabine IV over 15 minutes on days -5 to -2, alemtuzumab IV over 2 hours on days -5 to -1, and melphalan IV on day -1. * Donor stem cell transplant: Patients undergo stem cell transplantation on day 0 with filgrastim (G-CSF)-mobilized peripheral blood stem cells or bone marrow stem cells. * Graft-versus-host disease (GVHD) prophylaxis: Patients receive cyclosporine IV or orally on day -1 to 30 and taper to day 100. * Donor lymphocyte infusion (DLI) therapy: Patients with evidence of disease progression, mixed chimerism, or low level residual disease undergo DLI every 3 months for up to 15 months in the absence of GVHD. After completion of study, patients are followed every 3 months for 2 years.
Interventions
BIOLOGICALalemtuzumab
BIOLOGICALdonor lymphocytes
DRUGcarmustine
DRUGcytarabine
DRUGetoposide
DRUGmelphalan
PROCEDUREallogeneic bone marrow transplantation
PROCEDUREperipheral blood stem cell transplantation
Sponsors
Cancer Research UK
Study design
Allocation
NON_RANDOMIZED
Primary purpose
TREATMENT
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
DISEASE CHARACTERISTICS: * Histologically confirmed diagnosis of mantle cell lymphoma * No relapsed or progressive disease * Achieved at least a partial remission following induction chemotherapy * HLA-matched donor available * Blood samples from both patient and donor available for chimerism studies * No central nervous system involvement PATIENT CHARACTERISTICS: * ECOG performance status 2-4 * Considered fit for transplant by treating physician * Serum bilirubin ≤ 1.5 times upper limit of normal * Alkaline phosphatase ≤ 2 times normal * Creatinine clearance ≥ 50 mL/min * Ejection fraction \> 50% (no inadequate cardiac function) * Not pregnant or nursing * Negative pregnancy test * No symptomatic respiratory compromise * No serious concurrent disease which would preclude allograft * No known serological positivity for hepatitis B, hepatitis C, or HIV * No history of a psychological illness or condition that would affect compliance * No previous malignancy within the past 5 years except nonmelanoma skin tumors or stage 0 (in situ) cervical carcinoma PRIOR CONCURRENT THERAPY: * See Disease Characteristics
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression-free survival | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall survival | — |
| Toxicity | — |
Outcome results
None listed