Single and Multiple Ascending Doses of AZD1981 in Japan

A Randomised, Placebo-Controlled, Double-Blind, Phase I Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Oral Doses of AZD1981 in Healthy Male Japanese and Caucasian Subjects

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00698282

Acronym

JSAD/JMAD

Enrollment

Registered

2008-06-17

Start date

2008-08-31

Completion date

2008-10-31

Last updated

2010-12-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Brief summary

The purpose of this study is to study safety, tolerability and pharmacokinetics of AZD1981 in healthy Japanese subjects

Interventions

DRUGAZD1981

Oral tablet, 250 mg single dose

DRUGPlacebo

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

MALE

Age

20 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy Japanese and Caucasian males

Exclusion criteria

* Other clinically relevant disease or disorders

Design outcomes

Primary

Measure	Time frame
Adverse events	All the time
Plasma drug concentration	Every hour

Secondary

Measure	Time frame
Clinical chemistry	day 1 and 9

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026