AZD1981

DRUG12 trials

Sponsors

AstraZeneca, Johns Hopkins University

Conditions

AsthmaAsthma PatientsChronic Idiopathic UrticariaChronic Obstructive Pulmonary DiseaseDrug InteractionHealthyHealthy Male VolunteerModerate to Severe COPD

Phase 1

Single and Multiple Ascending Doses of AZD1981 in Japan

CompletedNCT00698282

AstraZenecaHealthy

Start: 2008-08-31End: 2008-10-31Updated: 2010-12-01

AZD1981 Midazolam CYP4503A Induction Study

CompletedNCT00859352

AstraZenecaHealthy Male Volunteer

Start: 2009-03-31End: 2009-04-30Target: 28Updated: 2009-04-10

AZD1981 Bioavailability Study of Intravenous (IV) and Oral Formulations

CompletedNCT00918398

AstraZenecaHealthy, Postmenopausal, Surgically Sterile Women

Start: 2009-06-30End: 2009-07-31Target: 14Updated: 2009-07-30

Study to Assess the Metabolism, Excretion and Pharmacokinetics of [14C]AZD1981 in Healthy Male Volunteers

CompletedNCT01058447

AstraZenecaHealthy

Start: 2010-02-28End: 2010-03-31Updated: 2010-11-18

A Drug-drug Interaction Study to Investigate the Effects of AZD1981 on the Metabolism and Pharmacodynamics of Oral Contraceptives

CompletedNCT01110525

AstraZenecaOral Contraceptives

Start: 2010-05-31End: 2010-10-31Target: 28Updated: 2010-11-18

A Drug-Drug Interaction Study to Study the Effect of AZD1981 on Warfarin

CompletedNCT01199341

AstraZenecaPharmakokinetic

Start: 2010-10-31End: 2010-12-31Updated: 2011-02-09

A Drug-Drug Interaction Study Between AZD1981 and Pravastatin to Study the Effect of AZD1981 on the Kinetics of Pravastatin

CompletedNCT01254461

AstraZenecaDrug Interaction

Start: 2011-02-28End: 2011-04-30Target: 30Updated: 2011-04-29

Phase 2

Study to Assess the Efficacy and Safety of AZD1981 in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)

CompletedNCT00690482

AstraZenecaModerate to Severe COPD

Start: 2008-05-31End: 2008-12-31Updated: 2014-01-15

One Month Dose Response Study of AZD1981 in Asthma Patients Uncontrolled on Inhaled Steroids

CompletedNCT00758589

AstraZenecaAsthma

Start: 2008-09-30End: 2009-07-31Updated: 2014-02-26

14729-D9831C00002- 1 Month Biopsy Study

CompletedNCT00766415

AstraZenecaChronic Obstructive Pulmonary Disease

Start: 2008-11-30End: 2009-06-30Updated: 2014-02-28

Investigation of Efficacy, Safety and Tolerability of Once and Twice Daily Doses of AZD1981 in Asthmatic Patients

CompletedNCT01197794

AstraZenecaAsthma Patients

Start: 2010-10-31End: 2012-02-29Updated: 2013-11-06

Efficacy and Safety of Chemoattractant Receptor-homologous Molecule Expressed on T Helper Type 2 (CRTh2) Antagonist AZD1981 in Chronic Idiopathic Urticaria (CIU) Antihistamines

CompletedNCT02031679

Johns Hopkins UniversityChronic Idiopathic Urticaria

Start: 2014-01-31End: 2016-01-31Updated: 2017-07-12

Related Papers

Efficacy and safety of the CRTh2 antagonist AZD1981 as add-on therapy to inhaled corticosteroids and long-acting &beta;2-agonists in patients with atopic asthma

Drug Design Development and Therapy2018-05-0124 citations

Efficacy and safety of AZD1981, a CRTH2 receptor antagonist, in patients with moderate to severe COPD.

2013-07-0122 citations