Alzheimer's Disease
Conditions
Keywords
AZD3480, Warfarin, Drug interaction
Brief summary
The purpose of the study is to evaluate if AZD3480 and warfarin interact with each other or not, i.e. show the same or altered plasma concentration profiles when co-administered compared to administered alone.
Interventions
DRUGAZD3480
AZD3480 capsules qd, 12 days
DRUGPlacebo
Placebo capsules qd, 12 days
DRUGWarfarin
Warfarin: single dose on day 6
Sponsors
AstraZeneca
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
MALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Provision of signed written informed consent * Clinically normal physical findings and laboratory values
Exclusion criteria
* Clinically significant illness or clinically relevant trauma within three weeks before the first dose * History of clinically significant disease * Use of prescribed medication during the 2 weeks before administration of the first dose of investigational product
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PK variables | Frequent sampling occasions during days 5 and 6 |
Secondary
| Measure | Time frame |
|---|---|
| Safety variables (adverse events, blood pressure, pulse, safety lab) | During the whole treatment period |
Countries
Sweden
Outcome results
None listed