Obesity
Conditions
Keywords
obesity, hyperinsulinism, diazoxide, metformin
Brief summary
The purpose of this study is to determine whether there is an additive effect of metformine on the weight reduction of obese hyperinsulinemic men who are treated with diazoxide.
Interventions
Sponsors
Rijnstate Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
25 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* male * age 25-50 years * BMI 30-35 kg/m2 * stable body weight during 3 months before the start of the study * glucose \<= 6.0 mmol/L * C-peptide \>= 1.0 nmol/L * HbA1c \<= 6.0%
Exclusion criteria
* comorbidity * medication * serum creatinine \> 120 micromol/L * liver enzymes \> 2 times upper limits of normal * gout * alcohol use \> 2 alcoholic drinks a day * drug abuse * cessation of smoking less than 6 months ago
Countries
Netherlands
Outcome results
None listed