Intracerebral Hemorrhage
Conditions
Keywords
Deferoxamine, Safety, Intracerebral hemorrhage
Brief summary
Animal studies show that the breakdown of blood results in iron accumulation in the brain after brain hemorrhage (ICH); and that iron plays a role in brain injury in ICH patients. Deferoxamine (DFO) has been extensively used in clinical practice for more than 30 years to remove excessive iron from the body, and has been shown to provide some benefit in animal studies of ICH. Therefore, we plan to undertake this study to evaluate the safety and tolerability of treatment with DFO in patients with ICH, and to determine the maximal tolerated dose to be used in future studies to determine if treatment with DFO can improve the outcome of patients with ICH. Our main objectives are: 1) to evaluate the safety and tolerability of varying doses of DFO, by determining the treatment related adverse events, in patients with ICH; and 2) to determine the maximal tolerated dose to be adopted in subsequent studies to test the efficacy of DFO in improving outcome after ICH. We hypothesize that DFO is well-tolerated and has minimal serious adverse effects in patients with ICH; and that treatment with DFO will improve patients' outcome. The results can potentially bring into account new means to improve the outcome of patients with ICH. ICH is a frequent cause of disability and death. A successful study demonstrating the efficacy of iron-modifying therapy would be of considerable public health significance.
Detailed description
An open-label, safety, tolerability, and dose-finding study using the continuous reassessment method.
Interventions
Various dose-regimens ranging from 7 mg/kg to 125 mg/kg (with a maximum allowable total daily dose of 6000 mg at any of the tested dose tiers, regardless of patient's weight), administered daily by IV infusion for three consecutive days.
Sponsors
National Institute of Neurological Disorders and Stroke (NINDS)
Massachusetts General Hospital
Medical College of Wisconsin
Medical University of South Carolina
Hartford Hospital
Beth Israel Deaconess Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Age ≥ 18 years 2. The diagnosis of ICH is confirmed by brain CT scan. 3. The first dose of the study drug can be administered within 18 hours of ICH symptom onset. 4. Signed and dated informed consent is obtained 5. Stable clinical and neurological status. Patients whose clinical or neurological status significantly deteriorates compared to presentation prior to administration of the study drug will be excluded.
Exclusion criteria
1. Previous chelation therapy or known hypersensitivity to DFO products 2. Abnormal renal function (serum creatinine \> 2 mg/dl) 3. Known severe iron deficiency anemia 4. Planned surgical evacuation of ICH prior to administration of the study drug 5. Patients with suspected secondary ICH related to tumour, coagulopathy, ruptured aneurysm or arteriovenous malformation, or venous sinus thrombosis 6. Evidence of significant shift of midline brain structure (\> 10 mm) or herniation on imaging studies. 7. Deep coma (Glasgow Coma Score (GCS) = 3-5) upon presentation 8. Taking iron supplements or prochlorperazine 9. Patients with heart failure taking \> 500 mg of vitamin C daily 10. Known hearing impairment 11. Systolic blood pressure \< 100 mmHg or diastolic blood pressure \< 60 mmHg, confirmed by 3 consecutive readings 12. Significant chronic respiratory insufficiency 13. Known pregnancy (or positive pregnancy test), or breast-feeding 14. Patients known or suspected of not being able to comply with the study protocol due to alcoholism, drug dependency, incompliance, or any other cause. 15. Any condition which, in the judgement of the investigator, might increase the risk to the patient 16. Life expectancy of less than 90 days due to co-morbid conditions 17. Concurrent participation in another research protocol for investigation of another experimental therapy 18. Pre-existing Do Not Resuscitate (DNR) order, or indication that a new DNR order will be implemented within the first 48 hours of hospitalization. -
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dose-limiting toxicities | First 7 days of hospitalization or diacharge, whichever occurs earlier |
Countries
United States
Outcome results
None listed