Deferoxamine Mesylate

DRUG3 trials

Sponsors

Beth Israel Deaconess Medical Center, The George Institute

Conditions

Acute Intracerebral HaemorrhageAcute StrokeIntracerebral HemorrhageSpontaneous Intracerebral HemorrhageSupratentorial Intracerebral Haemorrhage

Phase 1

Dose Finding and Safety Study of Deferoxamine in Patients With Brain Hemorrhage

CompletedNCT00598572

Beth Israel Deaconess Medical CenterIntracerebral Hemorrhage

Start: 2008-07-31End: 2010-04-30Updated: 2018-01-16

Phase 2

Intracerebral Hemorrhage Deferoxamine Trial - iDEF Ttrial

CompletedNCT02175225

Beth Israel Deaconess Medical CenterIntracerebral Hemorrhage

Start: 2014-10-31End: 2018-05-30Updated: 2019-05-30

Phase 3

The Fifth INTEnsive pReventing Secondary Injury in Acute Cerebral Haemorrhage Trial Within ACT-GLOBAL

RecruitingNCT06763055

The George InstituteAcute Intracerebral Haemorrhage, Acute Stroke, Intracerebral Hemorrhage +2

Start: 2025-02-27End: 2028-01-01Target: 2000Updated: 2026-07-08

Related Papers

Evolution of Perihematomal Edema Mean Hounsfield Unit and Its Association with Clinical Outcome in Intracerebral Hemorrhage: A Post Hoc Analysis of the i-DEF Trial

Neurocritical Care2025-08-11

Early neurological improvement with deferoxamine after intracerebral hemorrhage: A post hoc analysis of the i-DEF trial

International Journal of Stroke2025-05-262 citations

Hemoglobin and Perihematomal Edema After Intracerebral Hemorrhage: A Post Hoc Analysis of the i-DEF Trial.

2025-05-211 citations

Effect of Deferoxamine on Trajectory of Recovery After Intracerebral Hemorrhage: A Post Hoc Analysis of the i-DEF Trial

Stroke2022-03-2148 citations

Heme as an inducer of cerebral damage in hemorrhagic stroke: potential therapeutic implications

Neural Regeneration Research2022-01-014 citations

Effect of Deferoxamine on Outcome According to Baseline Hematoma Volume: A Post Hoc Analysis of the i-DEF Trial

Stroke2021-11-1819 citations

Predicting long-term outcomes in acute intracerebral haemorrhage using delayed prognostication scores

Stroke and Vascular Neurology2021-03-2311 citations

Deferoxamine mesylate in patients with intracerebral haemorrhage (i-DEF): a multicentre, randomised, placebo-controlled, double-blind phase 2 trial.

2019-03-18184 citations