Coronary Stenosis, Carotid Stenosis, Myocardial Reperfusion
Conditions
Brief summary
To detect coronary artery disease by both coronary and carotid artery imaging and myocardial perfusion imaging using a new low mechanical index real time system.
Detailed description
The objective of this clinical study will be to visualize both coronary and carotid arteries as well as detect myocardial perfusion following a routine intravenous injection of Definity (0.05-0.20 millimeters), Optison (0.1-0.4 millimeters) or PESDA (0.05-0.2 mL). Following these injections , we will attempt to Contrast Pulse Sequencing on the Siemens Acuson Sequoia system to image both the coronary and carotid arteries, as well as the Myocardial perfusion.
Interventions
DRUGOptison
0.1-0.4 mL through intravenous injection at the beginning of the study.
DRUGDefinity
intravenous injection at 0.05-0.20 mL
DRUGPESDA
intravenous injections dosage 0.05-0.20 mL
Sponsors
University of Nebraska
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* subjects scheduled for routine echocardiogram to look for evidence of Coronary artery disease or a stress echocardiogram * women of child-bearing potential must be taking a medically approved form of birth control with a negative urine pregnancy test * be conscious and coherent, and be able to communicate effectively with study personnel * last eight patients will be diabetics who smoke * provide informed consent after receiving a verbal and written explanation of the purpose and nature of the study
Exclusion criteria
* severe valvular heart disease by Doppler Echocardiography * females of child-bearing potential who are not taking a medically approved method of birth control will be excluded. If the patient is pregnant she will be excluded. * patients who are allergic to blood or blood products will be excluded * have contraindication to Optison, Definity, or PESDA (pulmonary HTN, cardiac shunt) * non diabetics, non smokers
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Detection of coronary and carotid artery stenoses and perfusion defects during standard echocardiographic examination | 2-4 months | To determine whether this imaging scheme can detect both coronary and carotid artery stenoses as well as perfusion defects during a standard echocardiographic examination |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Visual analysis of coronary and carotid arteries and perfusion defects during standard echocardiogram examination | immediate | Visually analyze the coronary and carotid arteries as well as perfusion defects during a standard echocardiogram examination |
Outcome results
None listed