Cerebral Oxygenation
Conditions
Brief summary
In a prospective and randomized study protocol, three different blood pressure regulating agents (nitroprusside, nitroglycerine, sevoflurane) will be compared concerning their effect on the cerebral oxygen balance between both hemispheres during aortic coarctation repair. Cerebral and somatic saturation will be monitored non-invasively and continuously via optical sensors applied to the right and left forehead and the somatic regions. Arterial blood pressure, central venous pressure, heart rate and systemic saturation will be recorded continuously. Intermittently, arterial and venous blood gas analysis will be performed at 6 definite time intervals. The study ends at the end of the operation.
Interventions
DRUGnitroprusside
Administration of nitroprusside
DRUGnitroglycerine
Administration of nitroglycerine
DRUGsevoflurane
Administration of Sevoflurane
Sponsors
University Hospital, Ghent
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
No minimum to 18 Years
Healthy volunteers
No
Inclusion criteria
* All neonates and infants * Aged 0-18 year * With aortic coarctation requiring surgical correction without the additional use of cardiopulmonary bypass will be included.
Exclusion criteria
* All patients with an associated cardiac effect are excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cerebral saturation | During operation |
Countries
Belgium
Outcome results
None listed