Metabolic Changes in Hypothyroid Patients

Impact of Hypothyroidism on Glucose, Lipid, and Amino Acid Turnover

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00524238

Enrollment

Registered

2007-09-03

Start date

2004-03-31

Completion date

2006-08-31

Last updated

2008-02-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypothyroidism

Keywords

hypothyroidism, glucose turnover, clamp, insulin resistance, lipid turnover, amino acid turnover

Brief summary

Hypothyroidism is a frequent condition in danish women, but often overlooked. Along with fatigue one of the main symptoms is weight gain as a result to significantly decreased energy expenditure. This study was undertaken to elucidate changes in glucose, lipid and amino acid turnover in these patients.

Interventions

DRUGL-thyroxine

The hypothyroid patients receive usual treatment with L-thyroxine in our out patient clinic. The doctors there subscribe the medication, this study has no protocol regarding this, we observe the patients again after having been biochemically euthyroid for at least two months.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Newly diagnosed hypothyroidism with tsh over 40 mU/L, etiology chronic autoimmune thyroiditis * Healthy controls matched regarding sex, age and body mass index

Exclusion criteria

* Pregnancy, breastfeeding

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026