Nonarteritic Anterior Ischemic Optic Neuropathy
Conditions
Brief summary
Purpose: There are some controversies about the effect of Levodopa-Carbidopa on treatment of non-arteritic anterior ischemic optic neuropathy (NAION). This study was performed to evaluate the effect of Levodopa-Carbidopa on visual acuity, color vision, and visual field in patients with recent onset NAION (less than 6 weeks duration). Patients and Methods: In this double-blind randomized clinical trial, 13 patients were treated with levodopa-carbidopa and 12 patients took placebo for 3 weeks. Visual acuity, color vision, and visual field were tested before and at 4th, 12th, 16th, and 24th weeks after enrollment, and evaluated.
Interventions
Sponsors
Shahid Beheshti University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
50 Years to No maximum
Inclusion criteria
* age greater than 50 years old * first ophthalmic examination within 6 weeks after onset of disease * presence of optic disc swelling followed by optic atrophy within 6 weeks * altitudinal, central or generalized visual field defect * normal ESR
Exclusion criteria
* confirmed giant cell arteritis * history of any ocular surgeries * optic neuropathy due to acute bleeding * advanced diabetic retinopathy * uncontrolled glaucoma * any ocular disorders that cause visual acuity reduction rather than NAION
Countries
Iran
Outcome results
None listed