Glomerulonephritis, IGA Nephropathy
Conditions
Keywords
IgA nephropathy, probucol, valsartan, treatment, antioxidant, IGA nephropathy：a kind of glomerulonephritis,which IgA is the dominant immunodeposit in mesangial areas
Brief summary
a statement of the study hypothesis:the effect of valsartan in patients with IgA nephropathy have been proved,and the efficacy of probucol in combination with valsartan is to be proved in patients with IgA nephropathy. This is a prospective randomized controlled, double blinded pilot study to identify the efficacy of probucol in combination with valsartan in patients with IgA nephropathy. The renal function deterioration will be the primary outcome studied. The expected study duration will be 36 months.
Interventions
Sponsors
Guangdong Provincial People's Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Patients who fulfill the clinical and pathological criteria for IgA nephropathy * Age: 18-60 years * Renal biopsy diagnostic for IgA nephropathy based on immunohistologic staining for IgA that is greater than or equal to staining for IgG and IgM * Urinary protein excretion rate is within the range of 1-2.5g/day * Serum creatinine \<265.2umol/L at the time of randomization
Exclusion criteria
* Patients who refuse to be randomized for treatment * Patients who prefer treatment with conventional agents * Patients who are pregnant or plan for pregnancy * Patients who are pathologically proven severely or diffusely proliferative IgA nephropathy or crescent glomerulonephritis with \>= 50% segmental involvement of the glomeruli and should be treated with other agents,such as immunosuppressive agents or steroid * Clinical and histologic evidence of: * systemic lupus erythematosus * Henoch-Schonlein purpura * cirrhosis * chronic active liver disease * hepatitis B * hepatitis C * severe chronic diarrhea * active peptic ulcer disease * HIV * acute renal failure * malignant hypertension * severe heart diseases * malignant tumor * any systemic infection * pregnancy * Known contraindication to the administration of probucol and valsartan
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| urinary protein loss whithin 24 hours | 2-3years |
Secondary
| Measure | Time frame |
|---|---|
| renal function(serum Crea or eGFR) deterioration | 2-3years |
Countries
China
Outcome results
None listed