Probucol

DRUG16 trials

Sponsors

Guangdong Provincial People's Hospital, Korea Otsuka Pharmaceutical Co., Ltd., Otsuka Beijing Research Institute, Asan Medical Center, Seoul National University Hospital

Conditions

Age-related Cognitive DeclineArteriosclerosis ObliteransAtherosclerosis of ArteryAtherosclerosis, CerebralBrain IschemiaChronic Kidney DiseaseDementia of the Alzheimer TypeDiabetic Nephropathy

Phase 1

Pharmacokinetics and Safety Study of Probucol by Multiple Administration in Healthy Male Subjects

CompletedNCT01590901

Otsuka Beijing Research InstituteHealthy

Start: 2012-02-29End: 2013-01-31Updated: 2013-06-05

Dosage and Efficacy of Probucol-induced apoE to Negate Cognitive Deterioration

CompletedNCT02707458

Douglas Mental Health University InstituteAge-related Cognitive Decline, Dementia of the Alzheimer Type, Mild Cognitive Impairment Due to Alzheimer Disease

Start: 2016-04-30End: 2017-03-31Updated: 2018-01-31

Phase 3

Efficacy and Safety of Imported Probucol to Treat Hyperlipidemia

CompletedNCT01349010

Otsuka Beijing Research InstituteHyperlipidemia

Start: 2011-04-30End: 2013-02-28Updated: 2013-06-05

Probucol for Symptomatic Intracranial and Extracranial Artery Stenosis

RecruitingNCT06225752

First Affiliated Hospital of Wannan Medical CollegeIschemic Stroke, TIA

Start: 2024-06-15End: 2026-10-31Target: 5452Updated: 2024-07-15

Phase 4

A Study of the Antioxidant Probucol Combined With Valsartan in Patients With IgA Nephropathy

CompletedNCT00426348

Guangdong Provincial People's HospitalGlomerulonephritis, IGA Nephropathy

Start: 2007-05-31End: 2013-01-31Updated: 2013-08-28

Safety and Pharmacokinetics of Probucol and Cilostazol

CompletedNCT00549978

Korea Otsuka Pharmaceutical Co., Ltd.Healthy

Start: 2007-10-31End: 2008-08-31Updated: 2022-03-04

Study of Cilostazol and Probucol to Assess Their Effects on Atherosclerosis Related Biomarker

CompletedNCT00823849

Otsuka Beijing Research InstituteArteriosclerosis Obliterans, Type 2 Diabetes Mellitus

Start: 2008-10-31End: 2010-03-31Updated: 2025-03-27

Pharmacokinetics Study for Probucol

CompletedNCT01000467

Korea Otsuka Pharmaceutical Co., Ltd.Healthy

Start: 2009-02-28End: 2009-09-30Updated: 2022-03-04

PreventIon of CArdiovascular Events in iSchemic Stroke Patients With High Risk of Cerebral HemOrrhage

Asan Medical CenterBrain Ischemia, Intracranial Hemorrhages

Start: 2009-06-30End: 2016-12-31Target: 1600Updated: 2015-12-24

A Clinical Study to Evaluate the Efficacy and Safety of Cilostazol and Probucol in Combination on Patients With Diabetic Nephropathy

CompletedNCT01252056

Otsuka Beijing Research InstituteDiabetic Nephropathy

Start: 2010-03-31End: 2012-12-31Updated: 2013-05-08

Effect of Probucol and/or Cilostazol on Mean IMT in Patients With Coronary Heart dIsease

CompletedNCT01291641

Seoul National University HospitalHyperlipidemias

Start: 2011-03-31End: 2017-03-31Updated: 2019-09-20

PreventIon of IMT Progression in iSchemic Stroke Patients With High Risk of Cerebral HemOrrhage-IMT Study

Asan Medical CenterBrain Ischemia, Intracranial Hemorrhages

Start: 2009-06-30End: 2016-12-31Target: 800Updated: 2015-12-24

The Effect of InTensive Statin in Ischemic Stroke With inTracranial Atherosclerotic Plaques

RecruitingNCT03753555

General Hospital of Shenyang Military RegionAtherosclerosis, Cerebral, Stroke, Ischemic

Start: 2018-12-01End: 2026-11-30Target: 100Updated: 2025-03-18

Unknown Phase

Probucol Combined With Valsartan in Reducing Proteinuria in Diabetes Nephropathy

Guangdong Provincial People's HospitalNephropathy, Type 2 Diabetes Mellitus

Start: 2008-05-31End: 2017-05-31Target: 170Updated: 2016-08-24

Efficacy of Probucol Combined with Statins Treatment for Ischemic Stroke

RecruitingNCT06604117

Xuanwu Hospital, BeijingAtherosclerosis of Artery, Ischemic Stroke, Lipid Disorder +1

Start: 2024-10-17End: 2027-10-31Target: 200Updated: 2025-03-25

Expanded Access Program for R007 (Probucol) Tablets in Adults With Mitochondrial Disease and Chronic Kidney Disease

RiboNova Inc.Chronic Kidney Disease, Mitochondrial Disease

Updated: 2025-04-17

Related Papers

Clinical study outcomes in IgA nephropathy: A systematic literature review and narrative synthesis.

2025-06-101 citations

Elevated Pulse Pressure and Recurrent Hemorrhagic Stroke Risk in Stroke With Cerebral Microbleeds or Intracerebral Hemorrhage

Journal of the American Heart Association2021-11-1517 citations

Newly diagnosed diabetes has high risk for cardiovascular outcome in ischemic stroke patients

Scientific Reports2021-06-2110 citations

Cilostazol versus aspirin in ischemic stroke with cerebral microbleeds versus prior intracerebral hemorrhage

International Journal of Stroke2020-07-1419 citations

Changes in High-Density Lipoprotein Cholesterol and Risks of Cardiovascular Events: A Post Hoc Analysis from the PICASSO Trial

Journal of Stroke2020-01-315 citations

Cilostazol Versus Aspirin in Ischemic Stroke Patients With High-Risk Cerebral Hemorrhage

Stroke2019-12-2028 citations

Prevention of cardiovascular events in Asian patients with ischaemic stroke at high risk of cerebral haemorrhage (PICASSO): a multicentre, randomised controlled trial.

2018-06-0177 citations

Potential interactions between cilostazol and probucol: a two-part, single-dose, open-label study in healthy Korean male volunteers.

2009-10-014 citations