Abscess
Conditions
Keywords
tissue plasminogen activator, intraabdominal, abscess, percutaneous drainage
Brief summary
To determine if instillation of tissue plasminogen activator into a percutaneously drained intra-abdominal abscess cavity results in faster resolution of the abscess compared to normal standard of care.
Detailed description
On day 0 Subjects will have Tissue Plasminogen Activator injected into a drainage tube and allowed to dwell in the intra-abdominal abscess for one hour before allowing it to drain by gravity. This will be repeated on day 1 and 2.
Interventions
The dosage of tPA is determined by the volume of drainage obtained when abscess is first drained. The same dose will be repeated on day 1 and 2.
OTHERNormal Saline
Normal Saline will be used rather than Tissue Plasminogen Activator for the Sham arm.
Sponsors
University Health Network, Toronto
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Intrabdominal abscess
Exclusion criteria
* Hypersensitivity to tPA * Recent stroke * Uncontrolled htn * Recent major hemorrhage * Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| time to eating | — |
| time to discharge | — |
| radiological evidence of resolution | — |
Secondary
| Measure | Time frame |
|---|---|
| cost comparison | — |
Countries
Canada
Outcome results
None listed