Tissue Plasminogen Activator

DRUG19 trials

Sponsors

University of Washington, National Heart, Lung, and Blood Institute (NHLBI), University of California, San Diego, University Health Network, Toronto, University of Calgary

Conditions

AbscessAcute Respiratory Distress SyndromeAll Patients With Ischemic Cerebrovascular Stroke Aged ≥18 Years of Both SexAll fibrinolytic agents either non&#45Aneurysmal Subarachnoid HemorrhageAngina PectorisCardiovascular DiseasesCentral Retinal Vein Occlusion

Phase 1

Intravenous Thrombolysis Plus Hypothermia for Acute Treatment of Ischemic Stroke

CompletedNCT00283088

University of California, San DiegoStroke

Start: 2003-10-31End: 2009-05-31Target: 130Updated: 2011-01-12

Intra-arterial Thrombolysis for Severe Recent Central Retinal Vein Occlusion

CompletedNCT01581411

Weill Medical College of Cornell UniversityCentral Retinal Vein Occlusion

Start: 2012-01-31End: 2015-11-30Updated: 2018-08-06

Effect of Intraventricular tPA Following Aneurysmal Subarachnoid Hemorrhage

WithdrawnNCT01878136

Rush University Medical CenterCerebral Aneurysm, Cerebral Vasospasm, Hydrocephalus +1

Start: 2015-03-31End: 2016-09-30Updated: 2015-11-11

Phase 2

Safety and Effectiveness of tPA in Intra-abdominal Abscesses

TerminatedNCT00417768

University Health Network, TorontoAbscess

Start: 2005-07-31End: 2013-11-30Updated: 2014-01-14

Intraventricular Tissue Plasminogen Activator (tPA) in the Management of Aneurysmal Subarachnoid Hemorrhage

University of CalgaryAneurysmal Subarachnoid Hemorrhage, Intraventricular Hemorrhage

Start: 2009-10-31End: 2012-04-30Target: 12Updated: 2010-11-11

Tenecteplase Versus Alteplase Before Endovascular Therapy for Ischemic Stroke

CompletedNCT02388061

Neuroscience Trials AustraliaIschemic Stroke

Start: 2015-03-23End: 2018-02-28Updated: 2018-03-30

Trial of Reduced Alteplase Dose for Parapneumonic Effusion (TRAPPE)

RecruitingNCT05766124

Chinese University of Hong KongPleural Infection

Start: 2024-11-01End: 2028-06-30Target: 30Updated: 2026-01-05

Phase 3

Myocardial Infarction Triage and Intervention Project (MITI)

CompletedNCT00000468

University of WashingtonCardiovascular Diseases, Coronary Disease, Heart Diseases +2

Start: 1988-04-30End: 1992-03-31Updated: 2016-02-09

Thrombolysis in Myocardial Ischemia Trial (TIMI III)

CompletedNCT00000472

National Heart, Lung, and Blood Institute (NHLBI)Angina Pectoris, Cardiovascular Diseases, Coronary Disease +3

Start: 1989-04-30End: 1995-06-30Updated: 2016-03-16

Thrombolysis in Myocardial Infarction (TIMI)

CompletedNCT00000505

National Heart, Lung, and Blood Institute (NHLBI)Cardiovascular Diseases, Coronary Disease, Heart Diseases +2

Start: 1983-04-30End: 1990-12-31Updated: 2016-03-16

Adjunctive, Low-dose tPA in Primary PCI for STEMI

CompletedNCT03335839

Population Health Research InstituteMyocardial Infarction, Percutaneous Coronary Intervention

Start: 2018-04-01End: 2025-02-12Updated: 2025-09-26

Impact of Tissue Plasminogen Activator (tPA) Treatment for an Atypical Acute Respiratory Distress Syndrome (COVID-19)

WithdrawnNCT04453371

Negovsky Reanimatology Research InstituteAcute Respiratory Distress Syndrome

Start: 2020-10-15End: 2021-02-15Updated: 2021-03-12

Phase 4

Use of Tissue Plasminogen Activator in the Clearance of Chronic Subdural Hematomas

CompletedNCT05491356

Hamilton Health Sciences CorporationFibrinolytic; Hemorrhage, Hematoma, Subdural

Start: 2023-05-11End: 2024-05-30Updated: 2026-03-12

Unknown Phase

Comparison of Different TRansesophageal Echocardiography Guided thrOmbolytic Regimens for prosthetIc vAlve Thrombosis

CompletedNCT01451320

Kartal Kosuyolu Yuksek Ihtisas Education and Research HospitalProsthetic Valve Thrombosis

Start: 1993-01-31End: 2009-12-31Updated: 2011-10-13

Comparison of Different TRansesophageal Echocardiography Guided thrOmbolytic Regimens for prosthetIc vAlve Thrombosis

CompletedNCT01451320

Kartal Kosuyolu Yuksek Ihtisas Education and Research HospitalProsthetic Valve Thrombosis

Start: 1993-01-31End: 2009-12-31Updated: 2011-10-13

Thrombolytic Care During Inter-hospital Transfer

CompletedNCT02752256

University of IowaStroke

Start: 2015-10-31End: 2017-10-31Updated: 2019-07-05

Regisry of the Stroke Patients in Assiut University Hospital

Assiut UniversityAll Patients With Ischemic Cerebrovascular Stroke Aged ≥18 Years of Both Sex

Start: 2018-12-30End: 2018-12-30Target: 1Updated: 2018-01-08

Fibrinolytic-Associated Urticaria, Angioedema, and Type I Hypersensitivity Reactions from Various Indications

Active, not recruitingTCTR20190607003

No sponsorAll fibrinolytic agents either non&#45

Start: 2019-01-21Updated: 2026-03-30

Application of tPA in Suprachoroidal and Subretinal Hemorrhage

RecruitingNCT05736757

Second Affiliated Hospital, School of Medicine, Zhejiang UniversityOcular Trauma

Start: 2022-12-01End: 2026-07-31Target: 20Updated: 2023-02-21

Augmented Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for PE

SuspendedNCT06310018

Brigham and Women's HospitalPulmonary Embolism, Right Ventricular Dysfunction, Right Ventricular Failure

Start: 2027-01-01End: 2028-12-31Target: 60Updated: 2026-01-21

Related Papers

Intracoronary Low-Dose Recombinant Tissue Plasminogen Activator in Primary PCI for ST-Segment Elevation Myocardial Infarction and Large Thrombus Burden: A Randomized Trial.

2025-10-28

Association of Time to Thrombolysis With Early Reperfusion After Alteplase and Tenecteplase in Patients With Large Vessel Occlusion.

2024-03-1911 citations

Abstract 052: External Validation of the Prediction Model For Delayed Reperfusion in Patients with Incomplete Reperfusion: EXTEND‐PROCEED

Stroke Vascular and Interventional Neurology2023-11-01

Safety and Efficacy of Tenecteplase and Alteplase in Patients With Tandem Lesion Stroke: A Post Hoc Analysis of the EXTEND-IA TNK Trials.

2023-03-066 citations

Thrombectomy Outcomes With General vs Nongeneral Anesthesia

Neurology2022-10-2614 citations

Safety and Efficacy of Tenecteplase in Older Patients With Large Vessel Occlusion: A Pooled Analysis of the EXTEND-IA TNK Trials.

2022-01-1118 citations

Prevalence and Significance of Impaired Microvascular Tissue Reperfusion Despite Macrovascular Angiographic Reperfusion (No-Reflow).

2021-12-14110 citations

Tenecteplase vs Alteplase Before Endovascular Therapy in Basilar Artery Occlusion.

2021-01-0633 citations

Creatine kinase during non-ST-segment elevation acute coronary syndromes is associated with major bleeding

Open Heart2020-12-017 citations

Cost-Effectiveness of Tenecteplase Before Thrombectomy for Ischemic Stroke

Stroke2020-10-0754 citations

Low-Dose Alteplase During Primary Percutaneous Coronary Intervention According to Ischemic Time.

2020-03-0120 citations

Helicopter "Drip and Ship" Flights Do Not Alter the Pharmacological Integrity of rtPA.

2018-07-208 citations

Tenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke

New England Journal of Medicine2018-04-25817 citations

Tenecteplase versus alteplase before endovascular thrombectomy (EXTEND-IA TNK): A multicenter, randomized, controlled study

International Journal of Stroke2017-09-2784 citations

Comparison of different TEE-guided thrombolytic regimens for prosthetic valve thrombosis: the TROIA trial.

2013-02-01157 citations