Retinal Disease
Conditions
Keywords
intravitreal Avastin, BRVO, Macular edema
Brief summary
In this study we intend to evaluate the outcome of intravitreal avastin on improving the visual acuity and macular edema and late complications of BRVO like NVD and NVE
Detailed description
After diabetic retinopathy, vein occlusion is the second most common retinovascular disease. According to BVO study the only effective management of it is macular photocoagulation for macular thickening that persist after 3 months.But we may miss a golden time which resulted to photoreceptor degeneration due to macular edema during this period. VEGF inhibitors newly have been shown that may be effective on a wide range of retinovascular diseases that resulted to macular edema or new vessels formation. In this study we aim to show the outcomes of one of this VEGF inhibitors (bevacizumab) on complications of BRVO in a sham controlled clinical trial.
Interventions
Intravitreal injection of 125 mg Avastin
Sponsors
Shahid Beheshti University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients with acute BRVO with less than three month duration
Exclusion criteria
* vision less than 20/320 and vison more than 20/50 * duration more than 3 months * history of glaucoma and diabetic retinopathy * any media opacity that prevent funduscopy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Best corrected visual acuity | At 12 week |
| Macular thickness by OCT | At 12 week |
Secondary
| Measure | Time frame |
|---|---|
| Need for macular photocuagulation | At 12th week |
| Incidence of new vessel formation | At 12th week |
Countries
Iran
Outcome results
None listed