Chronic Kidney Failure
Conditions
Keywords
Advanced Chronic Renal Insufficiency, Benazepril
Brief summary
The purpose of this study is to further determine whether benazepril, could safely slow the progression of renal dysfunction in non-diabetic patients with advanced renal insufficiency.
Interventions
DRUGBenazepril
Sponsors
Southern Medical University, China
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
1. serum creatinine concentration 1.5-5.0 mg/dL (133-442 µmol/L) 2. creatinine clearance 20 to70 mL/min/1.73 m2, with variations of less than 30 percent in the three months before the screening evaluation 3. non-diabetic renal disease 4. persistent proteinuria (defined as urinary protein excretion greater than 0.3 g/day for three or more months without evidence of urinary-tract infection or overt heart failure \[New York Heart Association class III-IV\]).
Exclusion criteria
* immediate need for dialysis; treatment with corticosteroids, non-steroidal anti-inflammatory drugs or immunosuppressive drugs; renovascular disease; myocardial infarction or cerebrovascular accident in the year preceding the trial; connective-tissue disease; obstructive uropathy.
Outcome results
None listed