Adhesion of Flexor Tendon of Hand
Conditions
Keywords
Flexor Tendon Adhesions, Zone II of the Hand
Brief summary
The purpose of this study is to dissolve flexor tendon adhesions associated with failed tendon repair surgery.
Detailed description
In an open label study, collagenase injection therapy was investigated in 3 subjects for it's ability to lyse flexor tendon adhesions in zone II of the hand. Results indicate that two of three subjects had improved range of finger motion at the PIP and DIP joints. This may obviate the need for patients to have tenolysis hand surgery to correct the finger flexion contracture of the PIP and DIP joints. Detailed controlled studies remain to be done.
Interventions
DRUGCollagenase
Collagenase injection into adhesion restricting tendon gliding
injection of collagenase into adhesion restricting tendon gliding
Sponsors
Stony Brook University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* zone II flexor tendon adhesion of at least one finger
Exclusion criteria
* any chronic, serious or uncontrolled medical condition * inability to conform to study visits (12-15 per year)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Restoration of PIP and DIP joint motion. | 6 months |
Secondary
| Measure | Time frame |
|---|---|
| Hand Grip strength (kg) | 6 months |
Countries
United States
Outcome results
None listed