Collagenase
Sponsors
Pirkanmaan hyvinvointialue, State University of New York, Stony Brook University, Sunnybrook Health Sciences Centre, Matrizyme Pharma Corporation
Conditions
Acid Chemical Burn Of Cornea And Conjunctival SacAdhesion of Flexor Tendon of HandAdhesive CapsulitisAlkaline Chemical Burn Of Cornea And Conjunctival SacBenign Mucous Membrane Pemphigoid With Ocular InvolvementCelluliteChronic Coronary Total OcclusionsChronic Total Occlusions
Phase 1
Collagenase in the Treatment of Zone II Flexor Tendon Adhesions in the Hand
CompletedNCT00261209
Start: 2005-01-31End: 2008-01-31Updated: 2016-04-21
Collagenase Total Occlusion-1 Trial
CompletedNCT01271335
Start: 2009-11-30End: 2012-02-29Updated: 2012-03-23
The Improvement of Limbal Epithelial Culture Technique by Using Collagenase to Isolate Limbal Stem Cells
NCT02202642
Start: 2012-01-31End: 2015-12-31Target: 10Updated: 2014-07-29
Phase 2
Phase II Randomized Study of Collagenase in Patients With Residual Type Dupuytren's Disease
CompletedNCT00004409
Start: 1995-08-31End: 2004-04-30Target: 36Updated: 2015-03-25
Collagenase in the Treatment of Adhesive Capsulitis (Frozen Shoulder)
WithdrawnNCT00261196
Start: 2006-01-31End: 2009-01-31Updated: 2019-10-03
Collagenase in the Treatment of Cellulite
NCT00261144
Start: 2013-02-28End: 2014-03-31Target: 20Updated: 2012-12-12
Total Occlusion Study in Coronary Arteries - 5
CompletedNCT01753180
Start: 2014-04-30End: 2016-07-31Updated: 2016-07-11
A 2-stage study to evaluate single doses of MZ-004 at different dose levels in patients with chronic total occlusions. STAGE 1: Open label Training Stage. STAGE 2: Double-blind, randomized, Placebo-Controlled Stage. The TOSCA-5 Study (Total Occlusion Study in Coronary Arteries-5)
Active, not recruitingNL-OMON41937
Start: 2015-10-20Target: 25Updated: 2024-02-28
Phase 3
Phase III Randomized Study of Collagenase in Patients With Residual Stage Dupuytren's Disease
CompletedNCT00014742
End: 2004-04-30Target: 72Updated: 2015-03-25
Evaluate the Noninferiority of Medicines Treating Uninfected Pressure Ulcers.
WithdrawnNCT02004626
Start: 2015-01-31End: 2015-09-30Updated: 2015-07-16
DupuytrEn Treatment EffeCtiveness Trial (DETECT): a protocol for prospective, randomized, controlled, outcome assessor-blinded, three armed parallel 1:1:1, multicenter trial comparing efficacy
and cost effectiveness of collagenase clostridium histolyticum, percutaneous needle fasciotomy and limited fasciectomy as a short and long term treatment strategy in mild or moderate Dupuytren’s contracture
RecruitingCTIS2024-515110-40-00
Start: 2017-09-15Target: 50Updated: 2025-08-18