Treatment of High Blood Pressure Using Olmesartan With Hydrochlorothiazide Compared to an ACE Inhibitor With a Calcium Channel Blocker

A Study on the Efficacy and Safety of Olmesartan Medoxomil and Its Combination With Hydrochlorothiazide Compared With an ACE Inhibitor and Its Combination With a Calcium Channel Blocker in Patients With Stage 2 Hypertension

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00185120

Enrollment

152

Registered

2005-09-16

Start date

2005-09-30

Completion date

2006-09-30

Last updated

2012-01-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension

Keywords

Hypertension, angiotensin receptor blocker, calcium channel blocker, angiotensin converting enzyme inhibitor hydroclorothiazide

Brief summary

A comparison of 2 different combinations of high blood pressure medications to treat hypertension

Interventions

DRUGOlmesartan medoxomil

DRUGHydroclorothiazide

DRUGBenazepril

DRUGAmlodipine

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Greater than 18 years of age * Patients with high blood pressure

Exclusion criteria

* Hypertensive encephalopathy, stroke or transient ischemic attack within the past 6 months * History of myocardial infarction, percutaneous transluminal coronary revascularization, coronary artery bypass graft, and/or unstable angina pectoris within the past 6 months * Type 1 diabetes mellitus

Design outcomes

Primary

Measure	Time frame
Change in systolic blood pressure from the start of the study	—

Secondary

Measure	Time frame
Change in diastolic blood pressure from the start of the study	—
Percent of patients who achieve target blood pressure goals	—

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026