Heart Failure, Congestive
Conditions
Brief summary
The activity of the sympathetic nervous system seems to influence the uptake (and handling) of glucose by the skeletal muscle of the forearm. Conditions in which sympathetic activity is increased seem to inhibit/reduce forearm glucose uptake. Inversely a decrease in sympathetic activity seems to increase glucose uptake. This study analyzes the effect of alfa-adrenergic receptor blockade (counteracting sympathetic influence) on insulin-stimulated forearm glucose uptake in patients with increased sympathetic activity (patients with chronic heart failure).
Interventions
DRUGphentolamine
Sponsors
ZonMw: The Netherlands Organisation for Health Research and Development
Radboud University Medical Center
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Heart failure of at least New York Heart Association (NYHA) class II * Left ventricular ejection fraction (LVEF) \<= 40% * Age 18-75 years
Exclusion criteria
* Alfa-blockers, or beta-blockers with alfa-blocking activity (carvedilol) * Tricyclic antidepressants * Warfarin derivatives (acetylic salicylic acid and clopidogrel are allowed) * Hospitalisation in 6 weeks prior to the study * Any change in medication in 6 weeks prior to the study * Unstable angina * Orthopnoea * Known chronic disease of the autonomic nervous system * Diabetes mellitus * Oedema of the lower extremities, complicating the insertion of a venous catheter in a vein on the foot
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change in glucose uptake | — |
Countries
Netherlands
Contacts
Primary ContactMarc E.R. Gomes, MD
Outcome results
None listed