Antioxidant Functions of Lipoic Acid

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00065624

Enrollment

Registered

2003-07-31

Start date

2003-11-30

Completion date

2007-07-31

Last updated

2007-10-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypercholesterolemia

Keywords

Lipoic acid, F2-isoprostanes, endothelial dysfunction, natural product

Brief summary

The goal of this study is to determine whether a short treatment with lipoic acid, an antioxidant used in the treatment of diabetic neuropathy, improves blood vessel reactivity and decreases oxidant stress in persons with elevated blood cholesterol.

Detailed description

As per Brief Summary

Interventions

DRUGlipoic acid

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE

Eligibility

Sex/Gender

ALL

Age

50 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Lipid criteria for inclusion are a plasma LDL between 160 and 190 mg/dl (total cholesterol usually 240-285 mg/dl) * Less than 2 coronary risk factors, and already on a cholesterol-lowering diet.

Exclusion criteria

* Overt or clinical atherosclerosis * Diabetes * Currently taking cholesterol-lowering medication. * Subjects with other lipid disorders * Subjects taking supplemental lipoic acid, vitamin C, or vitamin E.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026