Dichloroacetate Kinetics, Metabolism and Toxicology

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00015015

Enrollment

100

Registered

2001-04-19

Start date

1994-12-31

Completion date

2002-10-31

Last updated

2006-09-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lactic Acidosis

Keywords

Dichloroacetate, Chlorinated hydrocarbons, Genetic disease, Toxicology, Biotransformation

Brief summary

Dichloroacetate (DCA) is a product of water chlorination and a metabolite of certain industrial solvents, thus making it a chemical of environmental concern. However, DCA is also used as an investigational drug for treating various diseases of adults and children, at doses far greater than those to which humans are normally exposed in the environment. Our research involves how DCA is metabolized by healthy adults and by children with a fatal genetic disease, congenital lactic acidosis (CLA) who are treated with DCA.

Interventions

DRUGDichloroacetate

Study design

Observational model

DEFINED_POPULATION

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

3 Months to 65 Years

Healthy volunteers

Yes

Inclusion criteria

Children with congenital lactic acidosis Healthy adult volunteers

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026