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Dichloroacetate

DRUG13 trials

Sponsors

National Institute of Environmental Health Sciences (NIEHS), University of Florida, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), AHS Cancer Control Alberta, Stanford University

Conditions

Acidosis, LacticBrain TumorChronic DiseaseDiabetes Mellitus, Type 1EndometriosisGlioblastomaHead and Neck CancerHead and Neck Cancers

Early Phase 1

Development of Agents to Diminish the Risk of Hypoglycemia-induced Brain Injury in Type 1 Diabetes
CompletedNCT03356457
Yale UniversityHyperglycaemia (Diabetic)
Start: 2017-11-30End: 2019-03-20Updated: 2021-01-22
Regulation of Brain Glucose Metabolism in Type 1 Diabetes
RecruitingNCT05317455
Yale UniversityDiabetes Mellitus, Type 1, Hypoglycemia Unawareness
Start: 2025-05-13End: 2026-06-30Target: 16Updated: 2025-07-03

Phase 1

A Phase I, Open-Labeled, Single-Arm, Dose Escalation, Clinical and Pharmacology Study of Dichloroacetate (DCA) in Patients With Recurrent and/or Metastatic Solid Tumours
CompletedNCT00566410
AHS Cancer Control AlbertaNeoplasms
Start: 2007-12-31End: 2013-03-31Updated: 2016-03-11
Study of the Safety and Efficacy of Dichloroacetate (DCA) in Glioblastoma and Other Recurrent Brain Tumors
CompletedNCT01111097
University of FloridaBrain Tumor, Glioblastoma
Start: 2010-04-30End: 2014-03-31Updated: 2015-09-22
Imaging and Biomarkers of Hypoxia in Solid Tumors
TerminatedNCT01123005
Stanford UniversityNeoplasms
Start: 2010-12-31End: 2015-08-21Updated: 2017-11-06
Metabolic Reprogramming Therapy for Treatment of Recurrent Head and Neck Cancers
CompletedNCT01163487
Daniel T. ChangHead and Neck Cancer, Head and Neck Cancers
Start: 2010-08-31End: 2016-02-29Updated: 2022-06-16

Phase 2

Evaluating the Effectiveness of a Dichloroacetate in MELAS Syndrome
NCT00068913
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)MELAS Syndrome
Start: 2000-03-31Target: 35Updated: 2005-06-24

Phase 4

Role of Preoperative Carbohydrates Drinks, Dichloroacetate and Exercise on Postoperative Muscle Insulin Resistance
NCT02469337
University of NottinghamInsulin Resistance
Start: 2012-05-31End: 2017-06-30Target: 40Updated: 2017-01-05

Unknown Phase

Dichloroacetate Kinetics, Metabolism and Toxicology
CompletedNCT00015015
National Institute of Environmental Health Sciences (NIEHS)Lactic Acidosis
Start: 1994-12-31End: 2002-10-31Target: 100Updated: 2006-09-04
Prevention of Dichloroacetate Toxicity
CompletedNCT00031161
University of FloridaAcidosis, Lactic, Chronic Disease
Start: 2001-09-30End: 2005-09-30Target: 30Updated: 2015-03-25
Pharmacotoxicology of Trichloroethylene Metabolites
TerminatedNCT00865514
University of FloridaHealthy
Start: 2011-08-31End: 2012-01-31Updated: 2015-06-03
Dichloroacetate Treatment of Congenital Lactic Acidosis Phase B: Expanded Access
NCT01797276
University of FloridaMitochondrial Enzyme Deficiencies
Updated: 2017-08-08
A Clinical Trial to Evaluate Dichloroacetate (DCA) as a Treatment for Endometriosis-associated Pain
CompletedNCT04046081
University of EdinburghEndometriosis
Start: 2019-11-19End: 2021-09-30Updated: 2024-06-13

Related Papers

Dichloroacetate as a possible treatment for endometriosis-associated pain: a single-arm open-label exploratory clinical trial (EPiC).
2021-03-1212 citations