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Tryptophan and Behavior Therapy for Cocaine Abuse - 1

Tryptophan and Behavior Therapy for Cocaine Abuse

Status
Completed
Phases
Phase 2
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00000324
Enrollment
200
Registered
1999-09-21
Start date
1997-03-31
Completion date
2001-04-30
Last updated
2017-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cocaine-Related Disorders

Brief summary

The purpose of this study is to assess the efficacy of tryptophan vs. placebo, and voucher payments vs. a control condition, in the treatment of cocaine dependence.

Detailed description

This clinical trial uses a 2 by 2 design to compare tryptophan to placebo, and voucher incentives vs. a control condition, in the outpatient treatment of cocaine dependence- using a relapse prevention model of treatment intervention.

Interventions

DRUGTryptophan

Sponsors

Johns Hopkins University
CollaboratorOTHER
National Institute on Drug Abuse (NIDA)
Lead SponsorNIH

Study design

Allocation
RANDOMIZED
Primary purpose
TREATMENT
Masking
DOUBLE

Eligibility

Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
No

Inclusion criteria

* Cocaine dependent

Exclusion criteria

* Physically dependent on drugs of abuse other than cocaine * Significant medical or psychiatric illness (besides substance abuse disorder) * Pregnant

Design outcomes

Primary

MeasureTime frame
Side effects—
Retention—
Cocaine use—
Cocaine craving—
Other drug use—
Psychosocial functioning—

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026