Heart failure Heart failure
Conditions
Interventions
Intervention group: ferric citrate 250mg 2 tablets orally every day for 16 weeks
Control group: No treatment. If hemoglobin is less than 10g/dL, oral iron supplementation other than ferric citrate. Ir
Sponsors
Hamano Takayuki
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Age 20 years or older 2.Heart failure with left ventricular ejection fraction less than 50% 3.Iron deficiency, defined by ferritin less than 100 ng/mL or ferritin less than 300 ng/mL and transferrin saturation less than 20% 4. Mild anemia (Hb>=10g/dL and Hb<13g/dL in men, Hb<12g/dL in women 5.Those who can perform cardiopulmonary exercise test 6.Those on the stable dose of medications for heart failure including RAS inhibitors, SGLT2 inhibitors,beta-blockers, or ARNI for more than 2 months 7. Those who consented for participation in this research
Exclusion criteria
Exclusion criteria: 1.Hemoglobin less than 10g/dL, decrease in hemoglobin more than 1g per month 2.History of gastrointestinal bleeding, surgery, or transfusion within 3 months 3.Expecting surgery in next 4 months 4.Pregnant or lactating women and women who intend to be pregnant 5.Those who are already receiving oral or intravenous iron treatment 6.Those who have experienced serious adverse events by oral iron in the past 7.Chemotherapy for malignancy 8.Hematological malignancy including myelodysplastic syndrome 9.Those on dialysis 10. Those on erythropoiesis stimulating agents or hypoxia-inducible factor prolyl hydroxylase inhibitors 11.Those who were considered to be inappropriate to participate in the study by treating physicians
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| % predicted peak VO2 measured by cardiopulmonary exercise testing | — |
Secondary
| Measure | Time frame |
|---|---|
| KCCQ score, left ventricular ejection fraction, BNP, ferritin, transferrin saturation, Hb, MCV, MCH, MCHC, RDW, hepcidin, BUN, creatinine, proteinuria | — |
Contacts
Public ContactShuichi Kitada
Nagoya City University Hospital
Outcome results
None listed