Gastric post-ESD ulcers Gastric post-ESD ulcers
Conditions
Interventions
In addition to the usual treatment (esomeprazole 20 mg 1T1x morning dose), cholestyramine 8g2x morning and evening for 4 weeks.
Sponsors
Tamura Shigeki
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients between the ages of 20 and 85 years old at the time of obtaining consent. 2) Patients with early stage gastric cancer or gastric adenoma who are eligible for ESD 3) Patients with written consent from the individual to participate in this study.
Exclusion criteria
Exclusion criteria: 1) Patients with two or more gastric lesions to be resected in pieces in a single treatment (excluding en bloc resection). 2) Patients with psychosis, alcoholism, drug addiction, or drug addiction that may affect compliance with the research protocol. 3) Patients who are breastfeeding or who may be pregnant 4) Patients with biliary atresia or hypersensitivity 5) Patients with intestinal obstruction and the cause of the obstruction is not yet known or treated. 6) Patients on oral statins 7) Patients taking cholestyramine or cholestimide 8) Other patients who are judged by the principal investigator to be unsuitable as subjects for this study. 9) Patients who are taking NSAIDs on time
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of ulcer healing at 4-5 weeks after ESD | — |
Secondary
| Measure | Time frame |
|---|---|
| Post ESD ulcer status (Forrest classification), intragastric bile acid concentration, gastric juice color, Frequency of posterior bleeding, rate of ulcer size reduction, and frequency of adverse events | — |
Contacts
Public ContactShigeki Tamura
Yokohama City University Hospital
Outcome results
None listed