A Pilot Study on Nutritional Guidance and Changes in Gut Microbiota in Lung Cancer Patients Undergoing ICI Therapy

A Pilot Study on Nutritional Guidance and Changes in Gut Microbiota in Lung Cancer Patients Undergoing ICI Therapy - Nutritional Guidance and Changes in Gut Microbiota in Lung Cancer Patients Undergoing ICI Therapy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000056598

Enrollment

Registered

2024-12-28

Start date

2025-04-01

Completion date

Unknown

Last updated

2025-07-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Advanced Stage NSCLC

Interventions

nutritional guidance

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria:

Exclusion criteria

Exclusion criteria: Minors (under 18 years old). Patients with a performance status (PS) of 2 or higher. Patients currently using or with a history of using antibiotics or proton pump inhibitors (PPIs). Patients with cachexia. Patients with inflammatory bowel disease. Patients with a history of ileus or at risk of other gastrointestinal passage obstructions. Patients with driver mutations (e.g., EGFR, ALK, ROS-1, BRAF, MET, RET, NTRK, KRAS G12C, HER2). Patients considered unable to provide informed consent independently due to cognitive decline or other reasons. Any other patients deemed unsuitable by the attending physician.

Design outcomes

Primary

Measure	Time frame
Changes in the gut microbiota before and after guidance	—

Countries

Japan

Contacts

Public ContactNobuhiko Seki

Teikyo University Hospital Department of oncology

niino@med.teikyo-u.ac.jp03-3964-1211

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Feb 4, 2026