Corneal epithelial stem cell deficiency: Patients who have dysfunction of the entire limbus with almost replaced by conjunctival epithelium, neovascularization and corneal scarring tissue.
Conditions
Interventions
Harvest of the oral mucosal tissue is conducted at the University of Tokyo Hospital. The tissue is transferred to Osaka University Hospital, and oral mucosal cell sheets are produced. The produced s
Sponsors
Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo
Department of Ophthalmology, Osaka University Graduate School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Total limbal stem cell deficiency 2) Entire corneal surface is covered by conjunctival tissue 3) Regardless of gender, and must be over 20 years old when the subjects agree with this project 4) The signed consent is required
Exclusion criteria
Exclusion criteria: 1) Subjects who are pregnant, plan to become pregnant, or are breast-feeding. 2) Subjects who have systemic infections (HBV, HCV, HIV, HTLV-1) 3) Subjects who have extremely severe dry eye 4) Subjects who have extensive oral mucosal scarring and impossible to obtain the oral mucosal tissue. 5) Subjects who are not unsuitable for this project by some complications (judged by the doctor in charge).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate a size of epithelial defect and conjunctivalized corneal surface area in first postoperative year. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Improved visual acuity 2. Improved corneal opacity 3. Improved corneal neovascularization 4. Expected eye complications 5. All adverse events | — |
Countries
Japan
Contacts
Public ContactTomohiko Usui
Graduate School of Medicine, The University of Tokyo Department of Ophthalmology
Outcome results
None listed