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then graft survival and stabilization of epithelial cells are attained.

3 trials

Sponsors

Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Department of Ophthalmology, Ehime University Graduate School of Medicine

Conditions

Bilateral corneal epithelial stem cell deficiency: Patients with severe intractable ocular surface disease who have dysfunction of the entire limbus with totally replaced by conjunctival epithelium, neovascularization and corneal scarring tissue. (*Corneal epithelial stem cell deficiency: It is possible to make the diagnosis by using slit lamp microscopy showing loss of the palisades of Vogt (POV) and a conjunctivalized corneal surface which also can be seen by characteristic fluorescein staininCorneal epithelial stem cell deficiency: Patients who have dysfunction of the entire limbus with almost replaced by conjunctival epithelium, neovascularization and corneal scarring tissue.Unilateral corneal epithelial stem cell deficiency: Patients who have dysfunction of the entire limbus with almost replaced by conjunctival epithelium, neovascularization and corneal scarring tissue.

Unknown Phase

Exploratory clinical trial of serum-, and feeder cell-free cultivated autologous corneal limbal epithelial cell sheet transplantation using human amniotic membrane for corneal epithelial stem-cell deficiency
Active, not recruitingJPRN-UMIN000012014
Department of Ophthalmology, Graduate School of Medicine, The University of TokyoUnilateral corneal epithelial stem cell deficiency: Patients who have dysfunction of the entire limbus with almost replaced by conjunctival epithelium, neovascularization and corneal scarring tissue.
Start: 2014-01-06Target: 3Updated: 2026-06-29
Clinical trial of cultivated autologous oral mucosal epithelial cell sheet transplantation for corneal epithelial stem cell deficiency
Active, not recruitingJPRN-UMIN000012260
Department of Ophthalmology, Graduate School of Medicine, The University of TokyoCorneal epithelial stem cell deficiency: Patients who have dysfunction of the entire limbus with almost replaced by conjunctival epithelium, neovascularization and corneal scarring tissue.
Start: 2012-12-01Target: 10Updated: 2026-06-29
Clinical trial of cultivated autologous oral mucosal epithelial cell sheet transplantation for corneal epithelial stem cell deficiency
Active, not recruitingJPRN-UMIN000012264
Department of Ophthalmology, Ehime University Graduate School of MedicineBilateral corneal epithelial stem cell deficiency: Patients with severe intractable ocular surface disease who have dysfunction of the entire limbus with totally replaced by conjunctival epithelium, neovascularization and corneal scarring tissue. (*Corneal epithelial stem cell deficiency: It is possible to make the diagnosis by using slit lamp microscopy showing loss of the palisades of Vogt (POV) and a conjunctivalized corneal surface which also can be seen by characteristic fluorescein stainin
Start: 2013-03-12Target: 10Updated: 2026-06-29