A Prospective clinical study of innovative Wuqinxi exercise intervention in delaying the occurrence of freezing of gait in Parkinson's disease

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ITMCTR

Registry ID

ITMCTR2000003767

Enrollment

Unknown

Registered

2020-08-27

Start date

2020-10-01

Completion date

Unknown

Last updated

2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson 's disease

Interventions

experimental group:innovative Wuqinxi

control group:low intensity stretching exercise

Eligibility

Sex/Gender

All

Age

45 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1) Patients who were diagnosed with PD according to the 2015 international MDS PD criteria; 2) no history of FOG (NFOGQ score =0); 3) PD patients at high risk of developing FOG (the risk value was accounted according to our established predicting model for FOG); 4) having received a stable anti PD medication therapy for at least 2 months ; 5) aged ranging from 45 to 85 years old.

Exclusion criteria

Exclusion criteria: 1) Patients were diagnosed with atypical parkinsonism, secondary parkinsonism or hereditary PD; 2) history of serous organic diseases (heart disease, hypertension, lung tuberculosis, nephritis, etc.); 3) history of serious arthritis, bone and joint diseases; 4) having regularly participated in sports exercises during the recent 2 months; 5) Mini Mental Stage Examination(MMSE) score was less than 23 points.

Design outcomes

Primary

Measure	Time frame
the incidence of freezing of gait;the difference value between Apathy scale score at baseline and AS score after intervention;	—

Secondary

Measure	Time frame
the difference value between MDS-UPDRS III score at baseline and the MDS-III score after intervention;the difference of the Bold signal of activated brain areas at baseline and after intervention;the difference value between HAMD score at baseline and HAMA score after intervention;the difference value between the gait parameters at baseline and the gait parameters after intervention;the difference value between PDQ-39 score at baseline and PDQ-39 score after intervention;the difference value between FAB score at baseline and FAB score after intervention;the difference value between CGI score at baseline and CGI score after intervention;the difference value between HAMA score at baseline and HAMA score after intervention;	—

Measure

Time frame

the difference value between MDS-UPDRS III score at baseline and the MDS-III score after intervention;the difference of the Bold signal of activated brain areas at baseline and after intervention;the difference value between HAMD score at baseline and HAMA score after intervention;the difference value between the gait parameters at baseline and the gait parameters after intervention;the difference value between PDQ-39 score at baseline and PDQ-39 score after intervention;the difference value between FAB score at baseline and FAB score after intervention;the difference value between CGI score at baseline and CGI score after intervention;the difference value between HAMA score at baseline and HAMA score after intervention;

—

Countries

China

Contacts

Public ContactJing Gan

Xinhua Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine

ganjing67@126.com+86 13661776561

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026