Gestational pruritic dermatoses, gestational atopic dermatitis and psoriasis. This study explores genetic susceptibility and immune inflammatory disturbances in pregnant women suffering from the above dermatoses, as well as their effects on early health outcomes of offspring.
Conditions
Interventions
Control group:No intervention
Sponsors
Shenzhen Maternity & Child Healthcare Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Underwent routine clinical NIPT at participating medical institutions. 2.Possess complete, accessible raw NIPT sequencing data (usually BAM/FASTQ format) and corresponding clinical reports. 3.Aged 18 years or older. 4.Voluntarily enroll in the study and sign informed consent to permit the research team to utilize their NIPT data, clinical medical records, and subsequent follow-up data.
Exclusion criteria
Exclusion criteria: 1.High-risk result for chromosomal aneuploidy on NIPT (e.g., T21/T18/T13). Such cases represent definitive pregnancy complications that may confound cutaneous conditions and pregnancy outcomes. 2.Unqualified NIPT data quality or missing key information, precluding secondary bioinformatic analysis. 3.Planned delivery outside the participating hospital system, making offspring outcome data unavailable for collection. 4.Conception via assisted reproductive technology with donor oocytes or donor embryos (discordant genetic backgrounds).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Genetic susceptibility loci and risk gene loci associated with maternal skin diseases during pregnancy;Association between maternal dermatoses and core offspring health outcomes; | — |
Secondary
| Measure | Time frame |
|---|---|
| Validation of potential biological mechanisms;Prediction performance and clinical application value of the combined risk prediction model; | — |
Countries
China
Contacts
Public ContactWu Bo
Shenzhen Maternity & Child Healthcare Hospital
Outcome results
None listed