Ischemic stroke
Conditions
Interventions
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >=18 years old; 2. Acute ischemic stroke with anterior circulation large vessel occlusion (intracranial internal carotid artery, M1 or M2 segment of middle cerebral artery) confirmed by imaging (CTA/MRA/DSA); 3. Endovascular thrombectomy (EVT) was planned; =24 hours from last known normal time to randomization; 4. 5. Baseline NIHSS score >=6; 6. In all patients who received endovascular thrombectomy, the imaging results showed successful recanalization of TICI>=2b; 7. Baseline ASPECTS score >=6 (based on admission CT or MRI); 8. mRS Score <=1 before onset; 9. Patients or their legally authorized representatives provided written informed consent for the study.
Exclusion criteria
Exclusion criteria: 1. Stroke due to non-atherosclerotic causes such as vasculitis, arterial dissection, moyamoya disease, and fibromuscular dysplasia; 2. CT/MRI showed intracranial hemorrhage on admission; 3. Treatment with a monoclonal antibody to PCSK9 within 1 month before enrollment; 3. 4. Treatment with PCSK9 siRNA (Infram) within 6 months before enrollment; 5. Known allergy to evolocumab or PCSK9 inhibitors; 6. Severe liver dysfunction (ALT or AST>3 times the upper limit of normal); 7. Severe renal insufficiency (eGFR220mmHg or diastolic blood pressure >120mmHg) is uncontrolled; 13. Known hereditary or acquired bleeding tendency, INR>3; 14. CT/MRI showed intracranial tumors (except meningioma); 15. CTA/MRA shows excessive tortuosity of cervical vessels, which may hinder EVT operation; 16. Other circumstances deemed inappropriate by the investigator to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients with mRS scores of 0–2 (functional independence) at 90 days.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of symptomatic intracranial hemorrhage (sICH) within 24 to 48 hours;Change in low-density lipoprotein cholesterol (LDL-C) levels from baseline to Day 7, Day 30, and Day 90;Change in the National Institutes of Health Stroke Scale (NIHSS) score from baseline to Day 5-7 or discharge (whichever occurs first);Distribution of the modified Rankin Scale (mRS) score at 90 days;Rate of LDL-C target achievement at 90 days;Recurrent stroke (ischemic or hemorrhagic) at 90 days;Proportion of patients achieving an mRS score of 0 to 1 at 90 days;Health-related quality of life assessed by the EQ-5D-5L questionnaire at 90 days;All-cause mortality at 90 days; | — |
Countries
China
Contacts
Public ContactBo Hu
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed