Postoperative delirium
Conditions
Interventions
Intervention group:remimazolam
Sponsors
Chongqing University Cancer Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age = 60 years; 2.Clinically or radiologically diagnosed with a malignant solid organ tumor; 3.Planning to undergo elective radical oncologic surgery (including thoracic, gastrointestinal, gynecological, urological, hepatobiliary, head and neck, breast, and orthopedic tumor surgery) under general anesthesia or combined anesthesia (general plus regional anesthesia), with an expected surgical duration of =2 hours and a postoperative hospital stay of at least 3 days. 4.Willing to participate and provide written informed consent for the study;
Exclusion criteria
Exclusion criteria: 1.Refusal or inability to provide written informed consent for study participation; 2.Preoperative delirium or dementia; 3.Blindness, deafness, or language disorder precluding effective communication; 4.History of schizophrenia, epilepsy, or Parkinson's disease prior to surgery; 5.Acute or subacute cerebral infarction, lacunar infarction, encephalomalacia secondary to prior intracerebral hemorrhage, or history of neurosurgery; 6.Intracranial space-occupying lesion (primary or metastatic); 7.Renal failure requiring dialysis, or hepatic failure with Child-Pugh score >5; 8.Known allergy to remimazolam;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium within 7 days; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative hospital length of stay;All-cause mortality within 30 days;Incidence of postoperative complications (excluding delirium) within 30 days;Length of ICU stay;Duration of delirium;Incidence of severe postoperative delirium within 7 days; | — |
Countries
China
Contacts
Public ContactXianzhang Zeng
Chongqing University Cancer Hospital
Outcome results
None listed