Postoperative Gastrointestinal Dysfunction
Conditions
Interventions
Sponsors
Nanjing Drum Tower Hospital
Eligibility
Sex/Gender
Male
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age 50-80 years. 2.Pathologically confirmed prostate cancer and scheduled for elective RARP. 3.ASA classification I-III. 4.Voluntary participation and provision of signed informed consent.
Exclusion criteria
Exclusion criteria: 1.Presence of clinically diagnosed chronic functional constipation, irritable bowel syndrome, gastroparesis, active inflammatory bowel disease, or any other known condition causing severe gastrointestinal motility disorders. 2.Presence of diseases that may significantly affect baseline inflammatory/immune status, including: active autoimmune diseases, acute infection within 1 month prior to screening, or long-term use of systemic immunosuppressive drugs. 3.Presence of conditions that may severely compromise the quality of upper abdominal ultrasound imaging, including: severe obesity; previous major upper abdominal surgery; massive ascites; or other anatomical abnormalities that, in the investigator's judgment, may prevent clear visualization of the standard gastric antrum section. 4.Presence of uncontrolled arrhythmias, second-degree or higher atrioventricular block, or presence of an implanted pacemaker/implantable cardioverter-defibrillator. Long-term regular use of medications known to significantly affect autonomic nervous system function or heart rate that cannot be paused preoperatively (see protocol appendix for specific drug list). 5.Presence of severe hepatic dysfunction or severe renal insufficiency. 6.Presence of auricular diseases, deformities, chronic infections, or active skin lesions at the stimulation target that may affect electrode contact or stimulation safety. 7.Presence of cognitive impairment, mental illness, or any other condition that, in the investigator's judgment, may render the patient unable to comply with the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to first postoperative flatus; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to first postoperative defecation;Incidence and severity of postoperative nausea and vomiting (PONV);Postoperative pain;Postoperative cumulative opioid consumption;Postoperative quality of recovery score;Postoperative length of hospital stay;Antral motility index;High-frequency power of heart rate variability;Interleukin-6;Interleukin-10;Tumor necrosis factor-alpha;Motilin;Acetylcholinesterase;Butyrylcholinesterase;Choline acetyltransferase;white blood cell;C-reactive protein; | — |
Countries
China
Contacts
Public ContactMa Zhengliang; Wang Xiaoyi
Nanjing Drum Tower Hospital
Outcome results
None listed