Primary membranous nephropathy
Conditions
Interventions
Control group:No intervention
Sponsors
School of Public Health, Guangxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. IMN Case Group: (1) Patients with initial onset whose renal biopsy pathology meets the diagnostic criteria for IMN; (2) Patients who have not previously used steroids or other immunosuppressive treatments; (3) PLA2R antibody positive; (4) Age between 18-75 years; (5) Patients provide informed consent. 2. Healthy Control Group: (1) No history of autoimmune diseases, malignancies, hypertension, diabetes, or other chronic diseases; (2) No gastrointestinal-related diseases in the past 3 months; (3) Age between 18-75 years; (4) Matched with the case group in terms of gender and age; (5) Patients provide informed consent.
Exclusion criteria
Exclusion criteria: 1. IMN Case Group: (1) Patients with autoimmune diseases, secondary glomerulonephritis, combined diabetes, or gastrointestinal diseases; (2) Those who have taken antibiotics, probiotics/prebiotics, or other microbiota preparations within one month before sample collection; (3) Pregnant or breastfeeding women. 2. Healthy Control Group: (1) Individuals with a history of coronary heart disease, diabetes, hypertension, or tumors; (2) Individuals with kidney diseases or other systemic diseases; (3) Those who have taken probiotics/prebiotics or other microbiota preparations within the past month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PLA2R Antibody;IgG4;Renal Function Markers (including serum creatinine, urea nitrogen, uric acid, cystatin C, eGFR);Urinary Markers (including urinary albumin, a1-microglobulin, microalbumin, 24-hour urine protein);Internal Exposure Levels of Environmental Pollutants (Heavy Metals, PAHs, PAEs);Gut Microbiota (Metagenomic Sequencing);Serum Untargeted Metabolites;Short-Chain Fatty Acids and Tryptophan Metabolites;Renal Tissue Transcriptome;Single-cell Sequencing of Renal Tissue; | — |
Countries
China
Contacts
Public ContactZou Yunfeng
School of Public Health, Guangxi Medical University
Outcome results
None listed