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Transcutaneous auricular vagus nerve stimulation reduces postoperative delirium in elderly patients through the cholinergic system: a prospective, randomized, controlled study

Transcutaneous auricular vagus nerve stimulation reduces postoperative delirium in elderly patients through the cholinergic system: a prospective, randomized, controlled study

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400092798
Enrollment
Unknown
Registered
2024-11-22
Start date
2024-12-14
Completion date
Unknown
Last updated
2024-12-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative delirium

Interventions

Sponsors

Beijing Friendship Hospital, Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 85 Years

Inclusion criteria

Inclusion criteria: (1) Patients aged 60 to 85 years, diagnosed with gastric or colorectal cancer, regardless of gender; (2) Patients who underwent laparoscopic resection of abdominal tumors under general anesthesia (gastric, colon, rectal); (3) BMI of 18 kg/m^2 to 30 kg/m^2. Body mass index (BMI) = weight (kg) / height (m)^2; (4) ASA classification (American Society of Anesthesiologists classification) of I-III; (5) Voluntarily participate in this study and sign the informed consent form.

Exclusion criteria

Exclusion criteria: (1) Patients with local skin infection or injury in the concha area; (2) illiterate or with severe visual or hearing impairment, unable to communicate with the surgeon; (3) patients with a history of cognitive impairment or mental illness, or dementia, Parkinson's disease; (4) history of substance abuse; (5) Mini-Mental State Examination (MMSE) score of <=23 before surgery; (6) patients with preoperative pain and currently taking central analgesic drugs, opioid addicts and dependent individuals; (7) patients with severe liver or kidney dysfunction; (8) patients with pacemaker implantation or with a clear electrocardiographic conduction disorder.

Design outcomes

Primary

MeasureTime frame
Incidence of postoperative delirium;

Secondary

MeasureTime frame
Severity of postoperative delirium;Postoperative recovery of gastrointestinal function;Postoperative pain;Postoperative nausea and vomiting;Biomarkers of postoperative delirium;Intraoperative anesthesia related parameters;Health economic indicators;Neural Function;

Countries

China

Contacts

Public ContactLixin An

Beijing Friendship Hospital, Capital Medical University

anlixin8120@163.com+86 138 1024 8120

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026