Perioperative Hemodynamics
Conditions
Sponsors
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. History of primary hypertension with blood pressure controlled within 160/90mmHg after standardized treatment; 2. ASA <= Class ?; cardiac function <= Class ?; 3. Plan to undergo major non-cardiac surgery, the expected operation time is at least 3 hours, and the expected hospital stay is at least 5 days; 4. BMI between 18-27.9 kg/m^2.
Exclusion criteria
Exclusion criteria: 1.Patients whose hypertension is not treated with regular medication; 2.Systolic blood pressure =180 and/or diastolic blood pressure =110mmHg on the first day before surgery; 3.Diagnosis of severe respiratory, cardiovascular, renal or hepatic dysfunction before surgery; 4.Allergies or contraindications to dexmedetomidine,benzodiazepines,opioids or their components; 5.Hemoglobin < 90 g/L; 6.Have a history of stroke or any other central nervous system disease within 6 months; 7.History of schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis or other mental diseases; 8.History of alcoholism or psychotropic drug dependence; 9.Unable to communicate due to severe visual, hearing or language problems; 10.Severe sinus bradycardia or II-III degree atrioventricular block.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The area under the curve where the blood pressure was higher or lower than 20% of the basal blood pressure ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Average real variability of systolic blood pressure;Sleep quality;Related inflammatory and stress biomarkers;Postoperative analgesia within 5 days;Postoperative recovery;Postoperative adverse reactions such as hypertension, hypotension, bradycardia, respiratory depression and dizziness within 48 hours after operation; | — |
Countries
China
Contacts
Public ContactYan Tao
National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences
Outcome results
None listed