Chronic periodontitis
Conditions
Interventions
Sponsors
Department of Special Consultation, Peking University School and Hospital of Stomatology
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Clinically diagnosed as severe chronic periodontitis, probing depth (PD)>6 mm; loss of attachment (AL) = 5 mm; alveolar bone resorption>1/2 root length; loose teeth. The inflammation is more obvious and may be accompanied by periodontal abscess. Secondary or tertiary root bifurcation lesions in posterior teeth. The patient needs to have more than 2 affected teeth with the first 3 characteristics mentioned above; If there are only 2 affected teeth, they must be non adjacent teeth located in different quadrants. 2. Aged from 18 to 70 3. No systemic diseases 4. No smoking habits or smoking cessation for more than 1 year
Exclusion criteria
Exclusion criteria: 1. Women during pregnancy 2. Patients whom have used antibiotics and/or non-steroidal anti-inflammatory drugs (NSAIDs) within 1 month prior to the trial 3. Patients whom have undergone surgical or non-surgical periodontal treatment in the 3 months prior to the trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| methylation age (DNAmAge); | — |
Secondary
| Measure | Time frame |
|---|---|
| inflammatory age (iAge); | — |
Countries
China
Contacts
Public ContactDeng Xuliang
Peking University School and Hospital of Stomatology
Outcome results
None listed